Author

Stefano De Castro

University of California, BerkeleyORCID 0009-0009-8497-3531Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Assay:protein structure· 2 Research Focus:protein structure prediction· 2 Approach:diffusion model· 1 Organism:human· 1 Approach:transformer / foundation model· 1

Frequent Co-Authors

Julie Deborah Forman-KayiD· 2 shared Oufan ZhangiD· 2 shared Teresa L. Head-GordoniD· 2 shared Zi Hao LiuiD· 2 shared Alan M MosesiD· 1 shared Alexander Miguel MonzóniD· 1 shared Hamidreza GhafouriiD· 1 shared Kunyang SuniD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBiophysics

Julie Deborah Forman-KayORCID

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2 papers

Recent·Most cited

BiophysicsNature CommunicationsPeer-reviewedOct 30, 2026

IDPForge: Deep Learning of Proteins with Global and Local Regions of Disorder

Stefano De Castro, Oufan Zhang, Zi Hao Liu…·Teresa L. Head-Gordon

IDPForge generates all-atom ensembles of intrinsically disordered proteins and regions using a transformer diffusion model, showing good agreement with experimental data.

1 citation

protein structuredeep learning

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BiochemistrybioRxivPreprintNov 24, 2025

AlphaFlex: Ensembles of the human proteome representing disordered regions

Zi Hao Liu, Oufan Zhang, Stefano De Castro…·Julie Deborah Forman-Kay

AlphaFlex generates atomistic conformational ensembles for human proteins with intrinsically disordered regions, integrating AlphaFold models and implicit bilayers for transmembrane proteins.

5 citations

humanprotein structure

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