Julie Deborah Forman-Kay

IDPForge generates all-atom ensembles of intrinsically disordered proteins and regions using a transformer diffusion model, showing good agreement with experimental data.

This study shows how phase separation alters the conformational dynamics of DNAJB1, priming it for HSP70 binding and stress granule disassembly.

The paper generates conformational ensembles of the 4E-BP2:eIF4E complex using smFRET and NMR data, revealing dynamic structural changes and new contact regions.

The paper investigates how competing factors in biomolecular condensates modulate the rate of poly(A) RNA deadenylation by CNOT7, revealing concentration-dependent increases and diffusion-related decreases in enzymatic efficiency.

The paper maps the functional landscape of the human intrinsically disordered proteome using evolutionary signatures to classify and predict IDR functions.

This study identifies PRRC2A, PRRC2B, and PRRC2C as stress granule proteins that regulate translation by interacting with the eIF3 complex and 48S PIC factors.

The paper identifies a novel TUBB mutation linked to both ciliopathy and tubulinopathy brain features, showing it impairs ciliogenesis by altering microtubule dynamics.

AlphaFlex generates atomistic conformational ensembles for human proteins with intrinsically disordered regions, integrating AlphaFold models and implicit bilayers for transmembrane proteins.

The paper introduces a zero-shot protein segmentation method using ProtT5 embeddings to identify and categorize functional protein segments without sequence conservation reliance.

This paper shows that CAPRIN1 condensates suppress FUS RRM aggregation despite increasing its concentration and unfolding it, by outcompeting homotypic intermolecular contacts.

This study shows that protein interactions, calcium, phosphorylation, and cholesterol regulate CFTR cluster formation on membranes through multivalent interactions and phase separation.

This study uses NMR to show CAPRIN1 condensates shift SOD1 folding towards unfolded states, promoting aggregation, while a zinc-bound dimeric form is more stable.

This study identifies functional relationships between TSC22D, WNK, and NRBP gene families in macromolecular crowding sensing and cell volume regulation across metazoans.

This study identifies glutamate as a co-agonist for acid-sensing ion channels (ASICs) that worsens ischemic brain damage, and presents a small molecule inhibitor that targets this interaction without affecting NMDARs.

The paper designs synthetic intrinsically disordered regions by minimizing molecular property distances to known IDRs, showing expected patterns in cells.

The paper reconstructs the spatiotemporal gene expression blueprint for C. elegans pharyngeal cuticle construction and identifies phase-separating proteins involved in cuticle remodeling.

This study maps RNA translation dynamics in the human brain using ribosome profiling, identifying thousands of novel translation events and brain-specific microproteins linked to schizophrenia.

The paper introduces a method to discover molecular features of intrinsically disordered regions using contrastive learning with evolutionary conservation.

The paper identifies a recurrent SHANK3 frameshift variant in Autism Spectrum Disorder, showing de novo mutations and variable expressivity.

This study shows that FUS-ALS mutants form cytoplasmic condensates that alter FMRP phase separation, leading to translation inhibition in motor neurons.

The paper identifies evolutionary signatures in intrinsically disordered regions that correlate with functional annotations and phenotypes.