Author

Eric A. Smith

Georgia Institute of TechnologyORCID 0009-0009-9282-5125Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1

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Assay:metabolomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Harrison B. SmithiD· 1 shared Joshua E. GoldfordiD· 1 shared Liam M. LongoiD· 1 shared Tatsuya Corlett· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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4 top collaborators · 6 mutual co-author links

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1 shared paperBioinformatics

Harrison B. SmithORCID

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1 paper

Recent·Most cited

BioinformaticsProceedings of the National Academy of SciencesPeer-reviewedAug 11, 2026

The History of Enzyme Evolution Embedded in Metabolism

Tatsuya Corlett, Harrison B. Smith, Eric A. Smith…·Liam M. Longo

This paper reconstructs the historical emergence of enzymatic folds using metabolic reaction networks, finding that enzyme evolution is embedded in metabolic interdependencies and that β-proteins dominated early metabolism.

1 citation

metabolomicsstatistical model

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