NeurosciencebioRxivPreprint
Plasmin, the product of tissue plasminogen activator (tPA) treatment for ischemic stroke, impairs human brain endothelial barrier integrity
James Jack Willis Hucklesby, Cynthia Yaxin Gao, E. Scott Graham, Catherine Elizabeth Angel
This study shows plasmin, generated from tPA treatment, directly impairs human brain endothelial barrier integrity by reducing junctional molecules.
DOI 10.64898/2026.05.27.728289