Catherine Felce

This study estimates biophysical parameters of gene expression in multiple vertebrate species and finds coordinated evolution under evolutionary systems drift and additional constraints on transcriptional bursting.

The paper develops a biophysical model to jointly analyze single-cell RNA and protein data, demonstrating its utility with simulated and 10x multiomic data.

This paper proposes a biophysical model for analyzing ATAC-seq data and evaluates its benefits for integrating multiome data with single-cell RNA-seq.