Author

Madhumitha Krishnaswamy

Tata Institute of Fundamental ResearchORCID 0009-0008-7527-415XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Evolutionary Biology· 2 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Organism:bacteria (other)· 2 Research Focus:chromatin & epigenetic regulation· 2 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Organism:multiple species· 1 Research Focus:phylogenetics / evolution· 1 Assay:protein sequence· 1

Frequent Co-Authors

Aswin Sai Narain SeshasayeeiD· 2 shared Alexander L. CopeiD· 1 shared Catherine FelceiD· 1 shared Joshua G. SchraiberiD· 1 shared Lior S. PachteriD· 1 shared Matthew W. PennelliD· 1 shared Meghna NandyiD· 1 shared Mohak ShardaiD· 1 shared

Activity by Year

2025-2025 · peak 3/yr

Co-Author Collaboration Network

8 top collaborators · 13 mutual co-author links

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2 shared papersBioinformatics

Aswin Sai Narain SeshasayeeORCID

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3 papers

Recent·Most cited

Evolutionary BiologybioRxivPreprintNov 24, 2025

Interspecific divergence of gene expression biophysics driven by both evolutionary systems drift and strong selective constraints on bursting rate

Catherine Felce, Joshua G. Schraiber, Madhumitha Krishnaswamy…·Matthew W. Pennell

This study estimates biophysical parameters of gene expression in multiple vertebrate species and finds coordinated evolution under evolutionary systems drift and additional constraints on transcriptional bursting.

DOI 10.1101/2025.11.24.690267

multiple speciesscRNA-seq

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BioinformaticsGenome Biology and EvolutionPeer-reviewedSep 25, 2025

The evolution of function in the DNA binding domain of the CRP/FNR family

Madhumitha Krishnaswamy, Aswin Sai Narain Seshasayee

The paper analyzes the evolutionary divergence of DNA binding and transcriptional activation functions in the CRP/FNR family across prokaryotic genomes.

3 citations

bacteria (other)protein sequence

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Evolutionary BiologyJournal of Molecular BiologyPeer-reviewedApr 29, 2025

The evolution of sequence specificity in a DNA binding protein family

Meghna Nandy, Madhumitha Krishnaswamy, Mohak Sharda, Aswin Sai Narain Seshasayee

This paper investigates how DNA binding proteins evolved sequence specificity by analyzing the IHF/HU family and reconstructing ancestral sequences.

2 citations

bacteria (other)DNA methylation

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