The FABRIC Cancer Portal: A Ranked Catalogue of Gene Selection in Tumors over the Human Coding Genome

Abstract

We present The FABRIC Cancer Portal, a comprehensive catalogue of gene selection in cancer covering the entire human coding genome (~18,000 protein-coding genes) across 33 cancer types and pan-cancer. Genes in the portal are ranked according to the strength of evidence for selection in tumor, based on rigorous and robust statistics. Gene selection is quantified by combining genomic data with rich proteomic annotations. The portal includes a selected set of cross-references to the most relevant resources providing genomic, proteomic and cancer-related information. We showcase the portal with known and overlooked cancer genes, demonstrating the usefulness of the portal via its simple visual interface that allows to pivot between gene-centric and cancer-type views. The portal is available at fabric-cancer.huji.ac.il.