Y. Zou

Restoring O-glycosylation and expression of MUC2 limits progression of colorectal cancer

This study shows that restoring MUC2 O-glycosylation and expression via rosiglitazone inhibits colorectal cancer progression by enhancing intestinal barrier function.

Systematically investigating and identifying bacteriocins in the human gut microbiome

The paper introduces IIBacFinder to identify unmodified class II bacteriocins in the human gut microbiome, showing their widespread distribution and biosynthetic potential.

Cooperativity among clustered κB sites within promoters and enhancers dictates transcriptional specificity of NF-κB RelA along with specific cofactors

Dehydrozaluzanin C- derivative protects septic mice by alleviating over-activated inflammatory response and promoting the phagocytosis of macrophages

DHZD reduces inflammation and enhances macrophage phagocytosis in septic mice, showing potential as an HDT agent for bacterial infections.

rarestR: An R package using rarefaction metrics to estimate α-diversity (species richness) and β-diversity (species shared) for incomplete samples

rarestR estimates α- and β-diversity for incomplete samples using rarefaction metrics and parametric extrapolations, offering visualization tools for curve fitting.

ATP13A1 engages GET3 to facilitate substrate-specific translocation

The paper shows ATP13A1 uses GET3 to translocate cleaved signal sequences to the ER in a substrate-specific manner, ensuring efficient and accurate protein localization.

Legacy of warming and cover crops on the response of soil microbial function to repeated drying and rewetting cycles

This study examines how warming and cover crops influence soil microbial function under repeated drying and rewetting cycles, finding that cover crops enhance microbial adaptation to drought.

Site Effects in Multisite Fetal Brain MRI: Morphological Insights into Early Brain Development

This study identifies key MRI acquisition factors affecting fetal brain morphology and shows that ComBat-GAM harmonization effectively reduces site effects while preserving developmental patterns.

Thermoprotection by a cell membrane-localized metacaspase in a green alga

This study identifies CrMCA-II, a metacaspase in Chlamydomonas reinhardtii, which provides thermoprotection through modulating plasma membrane fluidity, independent of its proteolytic activity.

ATG8 delipidation is not universally critical for autophagy in plants

This study shows that ATG8 delipidation is essential for autophagy in Chlamydomonas but dispensable in Arabidopsis, highlighting evolutionary divergence in autophagy mechanisms.

Targeting Ribosome Biogenesis as a Novel Therapeutic Approach to Overcome EMT-related Chemoresistance in Breast Cancer.

This study identifies ribosome biogenesis as a key driver of EMT/MET transitions in breast cancer and shows that targeting this pathway enhances chemotherapy efficacy against chemoresistant tumors.

Evidence for a reproductive sharing continuum in cooperatively breeding mammals and birds: consequences for comparative research

The paper shows that extreme reproductive skew is rare in cooperatively breeding species classified with restrictive definitions and provides updated datasets accounting for classification uncertainty.

Root branching in salt requires auxin-independent modulation of LBD16 function

The paper shows that salt stress modulates lateral root development through an auxin-independent pathway involving ZAT6 and LBD16.

Therapeutic immune cell engineering with an mRNA : AAV-Sleeping Beauty composite system

The paper introduces a composite gene delivery system called MAJESTIC for efficient and stable engineering of therapeutic immune cells, showing improved cell viability and transgene expression compared to existing methods.

Homeostatic control of an iron repressor in a GI tract resident

The paper shows that Hap43, an iron-responsive transcription factor, is degraded under high iron conditions in C. albicans, leading to antioxidant gene activation and enhanced gut colonization.

From whole genome to probiotic candidates: a study of potential Lactobacillus strain selection for vaginitis treatment

This study identifies two Lactobacillus strains with probiotic properties for vaginitis treatment using genomic analysis, in vitro tests, and in vivo experiments.

Brevicidine, a bacterial non-ribosomally produced cyclic antimicrobial lipopeptide with a unique modus operandi

This study investigates brevicidine's antimicrobial mechanism against AMR Gram-negative pathogens and shows its efficacy in a mouse model.

Targeted Protein Degradation via Nanoparticles

This paper introduces a generic nanoparticle-based method for targeted protein degradation that avoids case-by-case design and enables degradation of both intracellular and extracellular targets.

Senescent cells develop PDK4-dependent hypercatabolism and form an acidic microenvironment to drive cancer resistance

This study identifies PDK4-dependent hypercatabolism in senescent cells that creates an acidic microenvironment, promoting cancer resistance and age-related pathologies.

Function and Cryo-EM structures of broadly potent bispecific antibodies against multiple SARS-CoV-2 Omicron sublineages

This paper designs and characterizes bispecific antibodies effective against multiple SARS-CoV-2 Omicron sublineages and determines their cryo-EM structures.

Oxonium Ion-Guided Ion Mobility-Assisted Glycoproteomics on the timsTOF Pro

This paper introduces a method using ion mobility on the timsTOF Pro to separate glycopeptides from non-modified peptides, improving glycoproteomics analysis of complex samples.

A Novel Selective ERK1/2 Inhibitor, Laxiflorin B, Targets EGFR Mutation Subtypes in Non-small-cell Lung Cancer

This study identifies Laxiflorin B, a novel ERK1/2 inhibitor, showing efficacy against EGFR mutant NSCLC through apoptosis induction and suppression of AREG/EREG.

Cell wall extensin arabinosylation is required for root directional response to salinity

The paper identifies a genetic locus associated with root bending in response to salinity, showing that extensin arabinosylation is required for directional root responses to salt.

Quantifying the capacity for assisted migration to achieve conservation and forestry goals under climate change

This study quantifies how assisted migration affects conservation and forestry goals under climate change using a vegetation model for 23 tree species in the western US.

SER: an R package to compute environmental regime over a certain time period

SER computes environmental regimes over time periods to improve understanding of environmental impacts on ecological communities and other fields.

An enzyme-based system for the extraction of small extracellular vesicles from plants

This study develops an enzyme-based method to extract plant extracellular vesicles, showing higher yield and therapeutic potential compared to traditional methods.

Bcl-xL restricts transcriptional, morphological and functional decompensation of β-cell mitochondria under chronic glucose excess

This study shows that Bcl-xL prevents mitochondrial dysfunction in beta-cells under chronic glucose stress by limiting mitochondrial ROS and maintaining gene expression.

Activation of transient receptor potential vanilloid 4 is involved in pressure overload-induced cardiac hypertrophy

This study shows TRPV4 activation contributes to pressure overload-induced cardiac hypertrophy through Ca2+/CaMKII-mediated NFκB-NLRP3 activation, suggesting TRPV4 as a therapeutic target.

A bacterial genome and culture collection of gut microbial in weanling piglet

The paper establishes a bacterial genome and culture collection of the piglet gut microbiome, revealing new species and functional insights.

Calcium/Calmodulin Dependent Protein Kinase Kinase 2 Regulates the Expansion of Tumor-induced Myeloid-Derived Suppressor Cells

This study identifies CaMKK2 as a regulator of MDSC expansion, showing its inhibition reduces tumor growth and enhances antitumor immunity.