No evidence for the presence and control of tumor growth by cytoplasmic stress granules in pancreatic cancer

Abstract

Cytoplasmic stress granules (SG) are attracting growing attention in cancer research1. As such, a study published in Cell2 has certainly served as a trigger for this trend which currently asserts that SG are a relevant therapeutic target. Here, we would like to express a warning about the conclusions of this article, as well as of the subsequent study3, and more generally on a methodological approach frequently used in research studying SG in cancer and which we believe to be misleading.