Paul Anderson

This study shows that G-quadruplex topology determines the functional outcome of G-rich oligonucleotides, with parallel topologies inhibiting translation while antiparallel ones do not.

This paper shows that MA-5 improves hearing loss and extends lifespan in mice by increasing NAD+ and SIRT1 through DNA-PK activation and mitochondrial function.

This study shows stress granules enhance survival of breast cancer cells under anoikis stress and identifies a signaling pathway that promotes their formation, suggesting therapeutic targeting of stress granules could improve cancer treatment.

The paper shows that cleavage of tRNA isodecoders generates tRNA-derived RNAs (tDRs) with differential activities in mRNA reporter translation, suggesting a mechanism for repurposing tRNAs for non-canonical functions.

The paper identifies stress-induced RNA G-quadruplexes in human cells and shows they regulate mRNA stability and stress response.

The paper shows that tRNA processing in human cells occurs primarily in the cytoplasm, challenging the notion that it is entirely nuclear.

This study uses APEX proximity-proteomics to analyze the spatio-temporal proteomic changes during stress granule disassembly, identifying novel proteins and revealing SUMOylation's role in ALS pathogenesis.

The paper shows that multiple RNase A family members cleave tRNAs under stress, producing tiRNAs that aid in translational reprogramming.