Pavel V. Ivanov

A tRNA-derived small RNA orchestrates cardioprotection through distinct cell-type-specific mechanisms

This study identifies a tRNA-derived small RNA that reduces cardiac fibrosis and hypertrophy through cell-type-specific mechanisms in mouse and human cardiac cells.

Chronic stress disrupts the network among stress granules, P-bodies, and motor proteins

This study shows chronic stress disrupts the myosin-SG-PB network and inhibits SG maturation through reduced MYH9 and UBAP2L levels.

tRNA-derived fragments elevated in Alzheimer's disease facilitate Tau aggregation

This study identifies tRNA-derived fragments (tRFs) as key regulators of Tau aggregation in Alzheimer's disease and shows their potential as therapeutic targets.

tRNA-derived fragments are elevated in the aging brain and may contribute to neurodegeneration

This study shows that tRNA-derived fragments (tRFs) accumulate in aging mouse brains and are elevated in human neurodegenerative conditions, suggesting a role in neurodegeneration.

Ribonuclease L Regulates Antiviral Responsiveness through Cleavage of XBP1 mRNA

The paper shows RNase L suppresses XBP1s, which fine-tunes antiviral responses by negatively regulating RIG-I-like receptors, RNase L, and PKR pathways.

Chronic stress antagonizes formation of Stress Granules

This study shows chronic stress prevents stress granule formation in response to acute stress by causing ribosome stalling and partial polysome preservation.

Differentiation stage-specific use of cap-independent and cap-dependent translation initiation in hematopoiesis

The paper shows that IRES/Cap translation increases during hematopoietic and epithelial differentiation under normal conditions, correlating with lower stemness.

Processing bodies promote lysosomal quality control and cell survival during recovery from lysosomal damage

This study identifies processing bodies (PBs) as critical for lysosomal quality control and cell survival during recovery from lysosomal damage, distinguishing their role from the acute damage response.

G-quadruplex topologies determine the functional outcome of guanine-rich bioactive oligonucleotides

This study shows that G-quadruplex topology determines the functional outcome of G-rich oligonucleotides, with parallel topologies inhibiting translation while antiparallel ones do not.

A mechanism that transduces lysosomal damage signals to stress granule formation for cell survival

The paper identifies a calcium-dependent pathway involving ALIX that links lysosomal damage to stress granule formation, promoting cell survival in response to various stressors.

Stress granule formation enables anchorage-independence survival in cancer cells

This study shows stress granules enhance survival of breast cancer cells under anoikis stress and identifies a signaling pathway that promotes their formation, suggesting therapeutic targeting of stress granules could improve cancer treatment.

Repurposing tRNA isodecoders for non-canonical functions via tRNA cleavage

The paper shows that cleavage of tRNA isodecoders generates tRNA-derived RNAs (tDRs) with differential activities in mRNA reporter translation, suggesting a mechanism for repurposing tRNAs for non-canonical functions.

HOXDeRNA activates a cancerous transcription program and super-enhancers genome-wide

This study identifies HOXDeRNA as a long non-coding RNA that derepresses glioma-specific transcription factors by interacting with PRC2 and RNA quadruplex structures, driving astrocyte transformation into glioma-like cells.

A Standardized Ontology for Naming tRNA-derived RNAs Based on Molecular Origin

The paper proposes a standardized ontology for naming tRNA-derived RNAs based on molecular origin to improve inter-study comparisons.

Nicked tRNAs are stable reservoirs of tRNA halves in cells and biofluids

The paper identifies nicked tRNAs as stable extracellular RNA species in biofluids and demonstrates methods to recover full-length tRNAs from these nicked forms.

Stress promotes RNA G-quadruplex folding in human cells

The paper identifies stress-induced RNA G-quadruplexes in human cells and shows they regulate mRNA stability and stress response.

Cytoplasmic processing of human transfer RNAs

The paper shows that tRNA processing in human cells occurs primarily in the cytoplasm, challenging the notion that it is entirely nuclear.

Spatio-temporal Proteomic Analysis of Stress Granule disassembly using APEX Reveals Regulation by SUMOylation and links to ALS pathogenesis

This study uses APEX proximity-proteomics to analyze the spatio-temporal proteomic changes during stress granule disassembly, identifying novel proteins and revealing SUMOylation's role in ALS pathogenesis.

Multiple ribonuclease A family members cleave transfer RNAs in response to stress

The paper shows that multiple RNase A family members cleave tRNAs under stress, producing tiRNAs that aid in translational reprogramming.