Learning RNA secondary structure (only) from structure probing data

Abstract

1. Introduction 1. Introduction 2. Methods 3. Experiments 4. Discussion References The structure of an RNA molecule is critical to its function. Structured regions in an RNA molecule permit or impede the binding of proteins and small molecules, resulting in downstream effects on gene expression [24, 16]. However, accurate determination of RNA structure is an involved process, requiring tedious experimentation [8, 1, 10] or careful analysis of evolutionary constraints [9]. As such, several computational methods have been developed to determine RNA structure in silico. In this work, we focus on methods that predict an RNAs secondary structure - the set of complementary Watson-Crick basepairs. These methods may be broadly ...