bioRxivBioengineering
In-Space Fabrication of Janus Base Nano-Matrix for Improved Assembly and Bioactivities
Anne YauiD, Maxwell Landolina, Mari Anne Snow, Pinar Mesci, Brandon Williams, James B. Hoying, Jana Stoudemire, Rayyanah Barnawi, Peggy Whitson, Rose Hernandez, Derek Duflo, Honglu Wu, Yupeng CheniD
Abstract
In-space manufacturing of nanomaterials is a promising concept while having limited successful examples. DNA-inspired Janus base nanomaterials (JBNs), used for therapeutics delivery and tissue regeneration, are fabricated via a controlled self-assembly process in water at ambient temperature, making them highly suitable for in-space manufacturing. For the first time, we designed and accomplished the production of JBNs on orbit during the Axiom-2 (Ax-2) mission demonstrating great promising and benefits of in-space manufacturing of nanomaterials.
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