W. Zhang

Glucokinase links metabolism and lineage plasticity in neuroendocrine prostate cancer via interaction with AKT1

This study identifies glucokinase (GCK) as a metabolic enzyme that regulates lineage plasticity in neuroendocrine prostate cancer through its interaction with AKT1.

ATG9A and ARFIP2 cooperate to regulate PI4P levels for lysosomal repair

The paper shows ATG9A and ARFIP2 work together to regulate PI4P levels for lysosomal repair during damage and bacterial infection.

Deletion of wheat alpha-gliadins from chromosome 6D improves gluten strength and reduces immunodominant celiac disease epitopes

This study deletes wheat alpha-gliadins from chromosome 6D to improve gluten strength and reduce celiac disease epitopes.

Construction of mirror-image RNA nanostructure for enhanced biostability and drug delivery efficiency

This paper constructs a mirror-image RNA nanostructure to improve biostability and drug delivery efficiency by conjugating siRNA and chemotherapy agents with enhanced endosomal escape.

Single-Cell and Spatial Transcriptomic Analyses Deciphering the Three-Layer Architecture of Human Tuberculosis Granulomas

This study uses single-cell and spatial transcriptomics to analyze human tuberculosis granulomas, revealing a three-layer structure and identifying potential therapeutic targets.

Membrane Curvature Promotes ER-PM Contact Formation via Junctophilin-EHD Interactions

This study shows PM curvature promotes ER-PM contact formation in cardiomyocytes via junctophilin-EHD interactions.

Target of rapamycin (TOR) regulates CURLY LEAF (CLF) translation in response to environmental stimuli

This study shows that TOR regulates CLF translation via an upstream open reading frame, affecting stress response and developmental gene induction.

AB-free kava enhances resilience against the adverse health effects of tobacco smoke in mice

This study evaluates AB-free kava's effects on tobacco smoke-exposed mice, showing it mitigates health deficits with safety, suggesting potential for reducing tobacco-related harm.

Selection of Fluorinated Aptamer Targeting RNA Element with Different Chirality

This study selects a 2-fluoro modified mirror-image RNA aptamer targeting a viral frameshift element with opposite chirality, showing improved stability and moderate binding affinity.

TransMetaSegmentation (TMS): a transcriptome-based segmentation method for spatial metabolomic data

This paper introduces TMS, a method that combines MALDI MSI data with single-cell spatial transcriptomics to segment cells and assign metabolites to cell types.

TLCellClassifier: Machine Learning Based Cell Classification for Bright-Field Time-Lapse Images

TLCellClassifier improves cell detection, tracking, and classification in time-lapse images using CNN, metric learning, and LSTM, outperforming existing tools in accuracy and efficiency.

PRDX6 dictates ferroptosis sensitivity by directing cellular selenium mobilization

The paper shows PRDX6 influences ferroptosis sensitivity by managing cellular selenium levels, which affects GPX4 function.

Quantitative imaging of loop extruders rebuilding interphase genome architecture after mitosis

The paper shows Cohesin replaces Condensin to rebuild genome architecture after mitosis, forming nested loop structures.

Discovery and binding site identification of a single-stranded DNA-binding protein that interacts with double-stranded DNA

This study identifies a single-stranded DNA-binding protein from E. coli F plasmid that also binds double-stranded DNA, revealing a previously unknown dsDNA-binding capability.

Cyclic di-GMP as an Antitoxin Regulates Bacterial Genome Stability and Antibiotic Persistence in Biofilms

The paper identifies a toxin-antitoxin system in biofilms where c-di-GMP regulates genome stability and antibiotic persistence by controlling HipH activity.

Cholestasis alters polarization and suppressor function of hepatic regulatory T cells.

This study shows cholestasis shifts hepatic Tregs to a Th17 phenotype and impairs their suppressor function, with bile acid levels influencing Treg activity and liver injury.

Effects of Drought and Salinity, etc. on Root Pressure of Dracaena sanderiana

This study measures root pressure in Dracaena sanderiana under drought, salinity, and other stress conditions, finding diurnal patterns and environmental impacts on pressure levels.

Opto-chemogenetic inhibition of L-type CaV1 channels in neurons through a membrane-assisted molecular linkage

This paper develops a method to inhibit L-type CaV1 channels in neurons using opto-chemogenetic tools, showing acute and potent inhibition through membrane-assisted molecular linkage.

ILC2s navigate tissue redistribution during infection using stage-specific S1P receptors

This study shows that ILC2s use different S1P receptors at distinct stages to migrate during infection, highlighting a shared vascular network for lymphocyte movement.

Exportin-1 functions as an adaptor for transcription factor-mediated docking of chromatin at the nuclear pore complex.

The paper identifies Crm1 as an adaptor that links transcription factors to chromatin at the nuclear pore complex, facilitating enhancer docking.

Epithelial NSD2 maintains FMOs-mediated taurine biosynthesis to prevent intestinal barrier disruption

The paper shows NSD2 maintains taurine biosynthesis via FMOs in intestinal epithelial cells, preventing barrier disruption in IBD.

Single cell profiling of bone metastasis ecosystems from multiple cancer types reveals convergent and divergent mechanisms of bone colonization.

The paper analyzes bone metastases from six cancer types using single-cell RNA-seq to identify three immune archetypes and their mechanisms of bone colonization.

Unbiased metastatic niche-labeling identifies estrogen receptor-positive macrophages as a barrier of T cell infiltration during bone colonization

Peripheral B Lymphocyte Serves as A Reservoir for The Persistently Covert Infection of Mandarinfish Siniperca chuatsi Ranavirus

This study identifies peripheral B lymphocytes as a viral reservoir for persistent and covert Mandarinfish Ranavirus (MRV) infection, revealing a unique reactivation mechanism distinct from other ranaviruses.

Glutamate (E299) is a key residue in the evolutionarily divergence of the SAM-dependent methyltransferases DnrK and RdmB in anthracycline biosynthesis

The paper identifies residue E299 as critical for the divergent catalytic functions of DnrK and RdmB in anthracycline biosynthesis, revealing distinct mechanisms for 10-hydroxylation and 4-O-methylation.

Formation of multinucleated osteoclasts depends on an oxidized species of cell surface associated La protein

This study identifies an oxidized form of La protein at the osteoclast surface, driven by ROS signaling, which promotes multinucleation and bone resorption.

NK Cell Exhaustion in Wilson's Disease Revealed by Single-cell RNA Sequencing Predicts the Prognosis of Cholecystitis

This study uses single-cell RNA sequencing to show NK cell exhaustion in Wilson's disease is linked to worse cholecystitis outcomes.

Engineered Ubiquitin Variants Mitigate Pathogenic Bacterial Ubiquitin Ligase Function

This paper identifies engineered ubiquitin variants that suppress Salmonella NEL SspH1 toxicity in yeast by modulating ubiquitination activity and cell cycle interference.

Aggresomes protect mRNA under stress in Escherichia coli

The paper shows that aggresomes in E. coli store mRNA under stress, aiding rapid recovery by protecting mRNA from degradation and facilitating translation reactivation.

Targeting IDH1-Mutated Oligodendroglioma with Acid Ceramidase Inhibitors

This study shows that inhibiting acid ceramidase (AC) induces apoptosis and improves survival in IDH1-mutated oligodendroglioma by increasing ceramide levels and activating both extrinsic and intrinsic apoptosis pathways.