Nature NeuroscienceNeurosciencePeer-reviewed journal article
Oligodendrocyte Precursor Cells Sculpt the Visual System by Regulating Axonal Remodeling
Yan Chun XiaoiD, Luigi PetruccoiD, Laura J. HoodlessiD, Rubén PortuguesiD, Tim CzopkaiD
Abstract
Many oligodendrocyte precursor cells (OPCs) do not differentiate to form myelin, suggesting additional roles of this cell population. The zebrafish optic tectum contains OPCs in regions devoid of myelin. Elimination of these OPCs impaired precise control of retinal ganglion cell axon arbor size during formation and maturation of retinotectal connectivity, and in consequence impaired visual acuity. Therefore, OPCs fine-tune neural circuit structure and function independently of their canonical role to make myelin.
- Citations
- 103
- FWCI
- 7.24
- Field percentile
- top 2%
Reproducibility ledger
Nobody has reported trying to reproduce this paper yet. Did you replicate an experiment or run the code? Your report saves the next lab a week.
Sign in to file a reproducibility report.
Related papers
- Oligodendrocyte precursor cells engulf synaptic inputs in an experience- and microglia-dependent manner
Yohan S. S. Auguste, Austin Ferro, … Lucas Cheadle·bioRxiv·Feb 10, 2022
- Neuronal synapses are stabilised by activity-dependent vesicular release from oligodendrocyte precursor cells
Emma Dumble, Denis Yuan, … Tim Czopka·bioRxiv·Feb 4, 2026
- Oligodendrocyte origin and development in the zebrafish visual system
Adrián Santos‐Ledo, Cristina Pérez‐Montes, … Almudena Velasco·The Journal of Comparative NeurologyPeer-reviewed·Dec 7, 2022
- Oligodendrocyte precursor cells prune axons in the mouse neocortex
JoAnn Buchanan, Leila Elabbady, … Nuno Maçarico da Costa·bioRxiv·May 29, 2021
- Functionally Distinct Subgroups of Oligodendrocyte Precursor Cells Integrate Neural Activity and Execute Myelin Formation
Roberta Marisca, Tobias Hoche, … Tim Czopka·Nature NeurosciencePeer-reviewed·Feb 17, 2020
- Geometric principles determining the morphology of oligodendrocyte precursor cells in brain white matter
Bartosz Kula, Maria Kukley·bioRxiv·Aug 5, 2025