Lucas Cheadle

This study identifies impaired glial-mediated synaptic refinement in FXS model mice, showing enhanced astrocyte-microglia signaling and synaptic over-engulfment as key features.

A poly(I:C) dose at E12.5 causes placental junctional-zone breakdown, amniotic inflammation and developmental defects in a male-only subset of embryos within 24 hours, dependent on maternal IL-6.

The paper identifies activity-dependent gene programs in human epileptic brain tissue and finds that some responses are conserved with acute stimulation, while others suggest metabolic and inflammatory dysregulation in epilepsy.

The paper presents a single-nucleus RNA-sequencing dataset of mouse visual cortex cells under sensory deprivation or stimulation, identifying 1,268 sensory-induced genes and their functional roles in neural circuit development.

This study shows that breast cancer disrupts hypothalamic GC rhythms by altering PVNCRH neuron activity, and that targeting these neurons can reduce tumor progression.

This study disrupts cholinergic retinal waves in mice and shows impaired visual cortex development and function, including altered retinotopy and sensory processing.

This study shows that Fn14, a cytokine receptor, acts as a molecular brake on neuronal activity in adult mice, influencing circadian rhythms, sleep, and memory.

The paper describes two methods to quantify synapse engulfment by OPCs, combining in vivo imaging and flow cytometry for high-throughput analysis.

This study shows OPCs engulf synaptic inputs in a microglia-dependent manner during experience-dependent plasticity in the mouse visual cortex.

This study shows that Fn14 and microglia influence transcription and chromatin accessibility in developing neurons, affecting synaptic function and neural circuit refinement.

This study shows that sensory lesioning causes microglia to eliminate synapses through ADAM10 and fractalkine signaling, revealing a neuron-to-microglia pathway for synaptic remodeling.