bioRxivSystems BiologyPreprint
Reconstructing Sample-Specific Networks using LIONESS
Abstract
We recently developed LIONESS, a method to estimate sample-specific networks based on the output of an aggregate network reconstruction approach. In this manuscript, we describe how to apply LIONESS to different network reconstruction algorithms and data types. We highlight how decisions related to data preprocessing may affect the output networks, discuss expected outcomes, and give examples of how to analyze and compare single sample networks.
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