Nature CommunicationsSystems BiologyPeer-reviewed journal article
Biological Process Activity Transformation of Single Cell Gene Expression for Cross-Species Alignment
Hongxu DingiD, Andrew P. BlairiD, Ying YangiD, Joshua M. StuartiD
Abstract
The maintenance and transition of cellular states are controlled by biological processes. Here we present a gene set-based transformation of single cell RNA-Seq data into biological process activities that provides a robust description of cellular states. Moreover, as these activities represent species-independent descriptors, they facilitate the alignment of single cell states across different organisms.
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- 30
- FWCI
- 1.74
- Field percentile
- top 15%
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