Chenqu Suo

STEER-seq enables pooled single-cell perturbation screening in hiPSCs by using defined genomic integration and barcode tracking to study transcription factor effects on cell identity.

This study uses single-cell transcriptomics to analyze T cell lymphomas, identifies developmental origins, and discovers SYK and TIM3 as potential therapeutic targets.

This study creates a single-cell multiomics atlas of B cell development in prenatal and adult bone marrow and in vitro models, identifying novel cell subsets and molecular signatures.

The paper creates a regulon atlas mapping TF activity across human cell types and uses it to link disease signatures to cell types and TFs, improving disease risk locus analysis.

Genes2Genes aligns single-cell trajectories using a Bayesian DP framework, revealing gene-level mismatches and highlighting differences in T cell differentiation between in vitro and in vivo states.

The paper constructs a human fetal lung cell atlas from 5-22 post conception weeks, identifying new cell states and regulators of epithelial fates.

The paper introduces a method to determine X-inactivation states in single-cell transcriptomes and uses it to infer cellular phylogenies in human females.

The paper maps the multi-organ functions of the human yolk sac during early development, revealing its roles in hematopoiesis, nutrition, and oxygen regulation.

The paper introduces a two-stage COVID-19 testing strategy combining point-of-care diagnosis with centralised high-throughput sequencing to enable population-scale testing.