A meta-analysis of in vitro release of hydrophilictherapeutics from contact lenses using mathematicalmodeling

Abstract

A meta-analysis was conducted to study the in vitro release of hydrophilic therapeutics from contact lenses. Fifty-two experiments were studied that measure the cumulative release of therapeutics from (mostly) commercial contact lenses placed in a vial. A mathematical model and a parameter fitting algorithm is presented to estimate the diffusion coefficient (D) and 50% therapeutic release time (T50) of all the experimental lens-therapeutic combinations. The mathematical framework was validated against previous studies. Statistical methods were used to analyze the relationships between lens materials, therapeutic properties, and predicted parameter values (D and T50). It was found that lens water content directly and moderately influences the estimated diffusion coefficient. More specifically, the median diffusivity of silicone hydrogel (SH) contact lenses was statistically different from conventional hydrogel (CH) lenses. Other lens and therapeutic properties dependencies on diffusivity were complex with special cases studied to elicit dependencies. A predictive tool was constructed to estimate the logarithm of 50% therapeutic release time, log(T50), given the lens water content and the therapeutic molecular volume and density. The statistical model explained 64% of the variability of the log(T50) and can be used in the preliminary stages of contact lens drug delivery development.