R. M. Rossi

Intranasal SARS-CoV-2 RBD decorated nanoparticle vaccine enhances viral clearance in the Syrian hamster model

This paper develops an intranasal nanoparticle vaccine against SARS-CoV-2 using a SpyCage scaffold decorated with RBD, showing enhanced viral clearance in Syrian hamsters without preventing infection.

Changes in biomarkers of metabolic stress during late gestation of dairy cows associated with colostrum volume and immunoglobulins content

This study examines metabolic stress biomarkers in late gestation dairy cows and their association with colostrum volume and immunoglobulin content, finding higher antioxidant potential and lower cholesterol in high colostrum producers.

Predicting transdermal fentanyl delivery using physics-based simulations for tailored therapy

This paper develops a physics-based digital twin to predict transdermal fentanyl delivery and tailor therapy based on patient age, showing increased pain relief and safety in older patients.

Inverse mechanistic modeling of transdermal drug delivery for fast identification of optimal model parameters

This paper uses inverse mechanistic modeling to rapidly determine optimal parameters for transdermal drug delivery, improving model accuracy with fewer simulations.

Predicting transdermal fentanyl delivery using mechanistic simulations for tailored therapy

This study uses mechanistic simulations to predict transdermal fentanyl delivery, showing significant variability in uptake by age and anatomical location, and demonstrating the potential of micron-sized reservoirs to enhance drug flux.

Relationship between Anti-Spike Protein Antibody Titers and SARS-CoV-2 In Vitro Virus Neutralization in Convalescent Plasma

This study finds a strong correlation between anti-RBD and anti-ECD IgG titers and in vitro virus neutralization titers in convalescent plasma, suggesting these titers can serve as surrogates for neutralizing activity.