Author

Eduardo A. Chacin Ruiz

University at Buffalo, State University of New YorkORCID 0009-0005-2553-5647Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Pharmacology & Toxicology· 2 Systems Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:statistical model· 2 Approach:experimental assay· 1 Organism:human· 1 Organism:rat· 1

Frequent Co-Authors

Ashlee N. Ford VersyptiD· 3 shared Katelyn E. Swindle‐ReillyiD· 3 shared Jabia M. ChowdhuryiD· 1 shared Matthew P. OhriD· 1 shared Samantha L. Carpenter· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

5 top collaborators · 8 mutual co-author links

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3 shared papersPharmacology & Toxicology

Ashlee N. Ford VersyptORCID

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3 papers

Recent·Most cited

Pharmacology & ToxicologybioRxivPreprintDec 30, 2025

Modeling and Design of Multi-layered Cylindrical Microcapsules for Intravitreal Controlled Release

Eduardo A. Chacin Ruiz, Katelyn E. Swindle‐Reilly, Ashlee N. Ford Versypt

This paper develops a computational model to optimize multi-layered microcapsules for controlled drug release in treating wet AMD, showing polymer thickness and chitosan layer impact release dynamics.

DOI 10.64898/2025.12.29.696951

statistical modeldrug response / drug discovery

𝕏 PostBluesky

Pharmacology & ToxicologyPharmaceuticsPeer-reviewedSep 9, 2025

Modeling and Design of Chitosan-PCL Bi-Layered Microspheres for Intravitreal Controlled Release

Eduardo A. Chacin Ruiz, Samantha L. Carpenter, Katelyn E. Swindle‐Reilly, Ashlee N. Ford Versypt

This study models and optimizes bi-layered chitosan-PCL microspheres for controlled drug release in intravitreal treatments of chronic retinal diseases.

2 citations

statistical modeldrug response / drug discovery

𝕏 PostBluesky

Systems BiologyJournal of Pharmaceutical SciencesPeer-reviewedDec 16, 2024

Computer Modeling of Bevacizumab Drug Distribution after Intravitreal Injection in Rabbit and Human Eyes

Jabia M. Chowdhury, Eduardo A. Chacin Ruiz, Matthew P. Ohr…·Ashlee N. Ford Versypt

This study develops spatial models of rabbit and human vitreous to analyze bevacizumab distribution and elimination, showing anterior elimination dominates in rabbits and both anterior/posterior elimination are important in humans.

8 citations

humanrat

𝕏 PostBluesky