Advanced Drug Delivery Systems

DCMax - A novel Delayed Cmax Drug Delivery System for Improved Chronotherapy

This study evaluates DCMax, a delayed Cmax drug delivery system, showing it delays peak plasma concentration and sustains release in healthy volunteers.

Sprayable in Situ Forming PEG Hydrogels for Intranasal Drug Delivery

This paper develops a PEG-based hydrogel for intranasal drug delivery that forms in situ without physiological triggers, improving drug residence time and bioavailability.

Development and pharmacological evaluation of an intranasal liposomal norbinaltorphimine formulation for the prevention of pain-induced negative affect

This paper develops an intranasal liposomal NorBNI formulation that selectively delivers KOR antagonists to the brain, reducing systemic exposure and off-target effects while improving pain-induced negative affect.

Sustained Delivery of a Shingles Subunit Vaccine Overcomes Age-Related Declines in Humoral and Cellular Immunity Relative to Shingrix

This study develops a hydrogel-based vaccine delivery system that enhances immune responses and reduces reactogenicity in aged mice compared to Shingrix.

Suprachoroidal Delivery of Anti-Angiogenic Peptide Microparticles Enables Sustained Activity with Favorable Ocular Safety

This study evaluates suprachoroidal delivery of AXT107 microparticles for treating retinal and choroidal vascular diseases, showing reduced neovascularization and favorable safety.

Incorporation of active cell-free expression lysates in chitosan coated alginate microcapsules

This paper demonstrates that chitosan-coated alginate microcapsules can protect cell-free gene expression lysates and proteins from degradation in the GI tract and enable controlled release in simulated intestinal conditions.

Hydrogel confinement enables subcutaneous delivery of vesicant antibody-drug conjugates

This paper develops a hydrogel that enables subcutaneous delivery of vesicant antibody-drug conjugates by confining them in a depot, reducing tissue damage while maintaining antitumor efficacy.

In-dwelling microfluidic device for precise and reliable intranasal drug delivery during freely-moving behavior

The paper develops a microfluidic device for precise intranasal drug delivery in freely-moving mice and validates its use for studying cocaine's effects.

Formulation Development of Topical Inserts Containing Doxycycline and Doxycycline Combined with Tenofovir Alafenamide and Elvitegravir for the Prevention of Sexually Transmitted Infections

This paper develops single and combined topical inserts for bacterial STI and HIV prevention, showing effective drug release and stability.

Intrinsically Disordered Protein Coating for Oral Delivery of Peptide Drugs

This paper introduces a synthetic intrinsically disordered protein coating that enhances oral delivery of peptide drugs by protecting them from gastric acid and enabling targeted intestinal release.

Nose-to-Brain Administration of Cannabidiol-Loaded Polymeric Micelles Improves the Core Behavioral Symptoms of Autism Spectrum Disorder

This study develops CBD-loaded polymeric micelles for nose-to-brain delivery in ASD, showing improved brain CBD concentration and behavioral symptom improvement in a rat model.

An injectable soft implant for long-acting, reversible, ultra-stable release of therapeutics

This paper develops an injectable hydrogel platform with poly(orthoester) microparticles for long-term, zero-order drug release, demonstrating in vitro and in vivo efficacy for up to 12 months.

Shifting Perspectives on Biotherapeutic Treatment in Ulcerative Colitis using Lipid Mesophases: Formulation Design and Preclinical Validation

This study develops and validates a localized delivery system for infliximab in ulcerative colitis, showing improved therapeutic efficacy and reduced systemic absorption.

First In Vivo Demonstration of Nose-to-Brain Drug Delivery of Memantine Using NosaPlugs Nasal Inserts

This study demonstrates that NosaPlugs nasal inserts can deliver memantine to the brain in mice, providing a proof-of-concept for nose-to-brain drug delivery.

Layer-by-Layer Polymeric Films: A Novel Approach to Buccal GLP-1 Delivery

This paper develops multilayer polymeric films for buccal delivery of GLP-1-RA and GDC, showing that triple-layer films provide sustained release and better mucosal compatibility than dual-layer films.

Synthetic Mucus Biomaterials Enable Localized Therapeutic Antibody Delivery in Inflammatory Bowel Disease

This study develops synthetic mucin-based hydrogels for localized delivery of anti-TNF- antibodies in IBD, showing improved retention and reduced systemic exposure.

Enhancing nasal retention: using the mucosal blanket to structure sprays

This study evaluates NoriZite(R), a nasal spray based on gellan polysaccharide, showing a 4-hour half-life and up to 6-hour retention in the nasal cavity, suggesting potential as a long-lasting barrier against airborne infections.

Enzyme-functionalized microparticles to open the vitreoretinal interface

This study demonstrates enzyme-functionalized microparticles that locally open the inner limiting membrane to enhance nanoparticle transport to retinal tissue in a porcine model.

Nanoparticle-in-Microparticle Oral Delivery System Based on Drug-Loaded Polymeric Micelles

This paper develops an oral drug delivery system using drug-loaded nanogels encapsulated in a mucoadhesive shell, showing improved controlled release and oral half-life compared to free drug.

Modeling and Design of Multi-layered Cylindrical Microcapsules for Intravitreal Controlled Release

This paper develops a computational model to optimize multi-layered microcapsules for controlled drug release in treating wet AMD, showing polymer thickness and chitosan layer impact release dynamics.

Identification and Validation of Small Molecules with Mucin-Selective Regiospecific Binding in the Gastrointestinal Tract

This study identifies small molecules that selectively bind to mucins in the gastrointestinal tract, enhancing localized drug delivery to the small intestine and stomach.

Taguchi/Machine Learning Hybrid Framework for Optimization of Particulate Drug Delivery Systems

The paper develops a hybrid Taguchi/machine learning framework to optimize particulate drug delivery systems, achieving high predictive accuracy and revealing key formulation factors.

A Strategic Blend of Stabilizing Polymers to Control Particle Surface Charge for Enhanced Mucus Transport and Cell Binding

The paper develops MECS NPs with controlled surface charge to enhance mucus transport and cell binding for improved mucosal drug delivery.

A meta-analysis of in vitro release of hydrophilictherapeutics from contact lenses using mathematicalmodeling

The paper develops a mathematical model and statistical analysis to predict therapeutic release from contact lenses based on lens and drug properties.

Engineered RVG29-Conjugated Chitosan for Enhanced Brain Delivery of Kisspeptin Agonists and Antagonists in Reproductive Health.

This paper develops a brain delivery system using RVG29-conjugated chitosan nanoparticles to deliver kisspeptin agonists and antagonists, showing enhanced brain accumulation and effective modulation of reproductive functions.

Hot cue: Physiologically controlled release from an in situ forming liposomal depot

This paper develops a thermoresponsive liposomal depot that releases drugs in response to physiological cues, demonstrating prolonged analgesia in rats and dogs.

Assessment of the pharmacological and safety profile of the small molecule MP-004 after topical eye drops administration

This study evaluates the pharmacological and safety profile of MP-004 after topical eye drops in mice, rabbits, and pigs, showing effective retinal concentrations and minimal systemic exposure.

Diet gel-based oral drug delivery system for controlled dosing of small molecules for microglia depletion and inducible Cre recombination in mice

This study develops a diet gel-based oral drug delivery system for controlled dosing of PLX5622 and Tamoxifen in mice, achieving high microglia depletion and inducible Cre recombination.

Intranasal sertraline for the investigation of nose-to-brain delivery to mitigate systemic exposure

This study develops intranasal sertraline formulations to reduce systemic exposure while maintaining brain delivery, showing comparable brain exposure at half the dose compared to oral administration in mice.

Photocrosslinked mucoadhesive hyaluronic acid hydrogel for transmucosal drug delivery

This study develops a photocrosslinked hyaluronic acid hydrogel for nasal drug delivery, showing improved mucoadhesion and stability compared to uncrosslinked versions.