Sign in
BioinformaticsbioRxiv
Preprint

BioPhasor: Decoding Cellular State Tensors from Multi-Omics Phasor Dynamics for Quantum Ready Systems Biology

Dibakar SigdeliD, Namuna PandayiD

Abstract

Integrating multi-omics data--transcriptomics, proteomics, metabolomics, single-cell--remains a fundamental challenge in systems biology. We present BioPhasor, a framework that encodes each measurement as a complex phasor z = ei{phi} on the compact N -torus TN, modelling the cell as phase-coupled oscillatory programs whose dissipative dynamics generate limit cycles and an attractor landscape. From this geometry we derive the Cell State Tensor (CST), a rank-3 tensor whose axes we root in measured multi-omics quantities: a pathway/module atlas on the regulatory axis and a directional central-dogma modality axis. Across nine scenarios on open public data (GEO, CPTAC), loaded through one unmodified data layer, we report verdicts honestly: four reproduce, three are partial, two do not. A data-driven cell-cycle axis lifts agreement with a reference method from 0.34 to 0.69; an explicit circadian origin cuts peak-time error from 10.6 to 1.4 h; and central-dogma coupling--mRNA phase organising protein amplitude--clears a surrogate null and is tumour-specific. Grounding the quantum-ready claim, the CST maps to a density-matrix formalism whose coherence and entropy match quantum-information counterparts, and the phasor circuit transpiles gate-for-gate to a variational quantum circuit, though no empirical advantage emerges. A single loader regenerates every reported number, and the code is released.

PDFDOI

02 /Specification & Classification

Click any tag to browse matching papers

Reproducibility ledger

Nobody has reported trying to reproduce this paper yet. Did you replicate an experiment or run the code? Your report saves the next lab a week.

Sign in to file a reproducibility report.