Group size planning of breedings of gene-modified animals
Vladislava MilchevskayaiD, Philippe BugnoniD, Emiel B. J. ten BureniD, Frank Brand, Achim TreschiD, Thorsten BuchiD
Abstract
Animal breeding is time-consuming, costly, and affected by stochastic events related to Mendelian genetics, fertility, and litter size. Careful planning is mandatory to ensure a successful outcome using the least number of animals, hence adhering to the 3Rs of animal welfare. We have developed an R package, accessible also through an interactive website, that optimizes breeding design and provides a comprehensive report suitable for any breeder of genetically defined traits.
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