Achim Tresch

Halfpipe quantifies RNA half-lives from metabolic labeling RNA-seq data, showing similar half-lives for constantly expressed RNAs in mitosis and G1 phase.

This study quantifies mRNA synthesis, nuclear export, and degradation rates genome-wide, finding nuclear export is slow and cytosolic degradation is fast, with some transcripts using alternative export pathways.

The paper introduces SPACO, a method for dimension reduction in spatial transcriptomics data that improves pattern detection by maximizing Moran's I and outperforms PCA.

The paper uses pseudotime analysis of single-cell RNA-Seq data to identify regulatory factors involved in the transition from multigenic to monogenic odorant receptor expression in mouse olfactory neurons.

The paper develops an R package and website to optimize breeding design for gene-modified animals, minimizing animal use while ensuring successful outcomes.

This study shows that HCN-channel dysfunction in neural progenitors causes microcephaly by disrupting cell cycle progression and proliferation in mice.

GenoGAM improves ChIP-seq differential occupancy analysis by using generalized additive models to avoid subjective binning, increasing sensitivity while controlling type I error.

GenoSTAN improves promoter and enhancer identification in 127 cell types and tissues, showing higher accuracy and better enrichment of genetic variants.