A Web-based Software Resource for Interactive Analysis of Multiplex Tissue Imaging Datasets
Allison CreasoniD, Cameron WatsoniD, Qiang Gu, Daniel PerssoniD, Luke SargentiD, Yu‐An CheniD, Jia‐Ren LiniD, Shamilene SivagnanamiD, Florian WünnemanniD, Ajit J. NirmaliD, Koei ChiniD, Heidi S. FeileriD, Hannah Holly, Lisa M. CoussensiD, Denis SchapiroiD, Björn Andreas GrüningiD, Peter Karl SorgeriD, Artem SokoloviD, Jeremy GoecksiD
Abstract
Highly multiplexed tissue imaging (MTI) are powerful spatial proteomics technologies that enable in situ single-cell characterization of tissues. However, analysis and visualization of MTI datasets remains challenging, and we developed the Galaxy-ME software hub to address this challenge. Galaxy-ME is a web-based, interactive software hub that enables end-to-end analysis and visualization of MTI datasets and is accessible to everyone. To demonstrate its utility, Galaxy-ME was used to analyze datasets obtained from multiple MTI assays in both normal and cancerous tissues. Galaxy-ME is a publicly available web resource.
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