Resveratrol enhances associative learning and memory function in C. elegans Models of Alzheimer's Disease: A chemotaxis-based behavioral analysis

Abstract

Alzheimers disease affects over 50 million individuals worldwide and is characterized by progressive cognitive decline through amyloid-{beta} plaque accumulation and neurofibrillary tangles. Current treatments provide limited therapeutic benefits, creating an urgent need for neuroprotective compounds. This study investigated resveratrols effects on associative learning and memory function in Caenorhabditis elegans models of Alzheimers disease using chemotaxis-based behavioral assays. Wild-type C. elegans and GMC101 transgenic worms expressing human A{beta} peptides were exposed to six experimental conditions combining E. coli OP50, sodium chloride, and resveratrol treatments. Chemotaxis index values were analyzed using two-way ANOVA with Tukeys post hoc testing across five independent replicates. Results showed resveratrol significantly enhanced chemotaxis performance in GMC101 worms, particularly under combined E. coli, NaCl, and resveratrol conditions (p < 0.0001). Two-way ANOVA revealed significant main effects for genotype (p = 0.002258) and treatment condition (p < 0.0001). GMC101 worms demonstrated 214% improvement in behavioral responses under optimal treatment conditions, suggesting partial restoration of learning-associated cognitive functions. These findings support resveratrols therapeutic potential for neurodegenerative diseases, though efficacy appears context-dependent and may require synergistic environmental stimuli for optimal effect.