Christopher V. Gabel

This study shows that early amyloid-β toxicity disrupts neuronal connectivity and function in C. elegans, distinct from normal aging, and identifies metabolic pathways involved in the effects.

This study shows that exposing oligodendrocyte-enriched cortical organoids to a specific medium during development enhances neuronal activity and maturation while preserving oligodendrocyte development.

This study uses C. elegans to show that isoflurane induction causes gradual neuronal disconnection and disorganization, reversing the dynamics seen during emergence from anesthesia.

The paper uses iPSC-derived neurons from centenarians to identify resilience signatures associated with longevity, showing enhanced stress response and specific transcriptional programs.

This study investigates ketamine's effects on neuronal activity in C. elegans, finding it induces global excitatory network oscillations by decoupling key interneurons.

CaNetiCs provides an open-source toolbox for standardized dimensionality reduction of neuronal calcium activity data, validating its utility on two experimental datasets.

This study identifies O-GlcNAc signaling's role in enhancing neuron regeneration in C. elegans by redirecting metabolism towards one-carbon metabolism and transsulfuration pathways.

This study identifies age-related disruptions in excitatory/inhibitory balance in C. elegans neurons, showing that inhibitory signaling loss and calcium channel mutations contribute to functional decline.

This study identifies compounds that promote axon regeneration using human iPSC-derived motor neurons and validates blebbistatin as a top hit in vivo.

The paper compares an Ytterbium-doped fibre femtosecond laser to other lasers, finding it more precise and capable of deeper tissue lesions.