Christopher W. Connor

Early Amyloid-β Toxicity Disrupts Nervous System Connectivity During Aging in Caenorhabditis elegans

This study shows that early amyloid-β toxicity disrupts neuronal connectivity and function in C. elegans, distinct from normal aging, and identifies metabolic pathways involved in the effects.

Neuronal Dynamics During Isoflurane Induction in Caenorhabditis elegans

This study uses C. elegans to show that isoflurane induction causes gradual neuronal disconnection and disorganization, reversing the dynamics seen during emergence from anesthesia.

Global excitatory synchrony: Ketamine induces global common-mode excitatory network oscillation by decoupling key interneurons

This study investigates ketamine's effects on neuronal activity in C. elegans, finding it induces global excitatory network oscillations by decoupling key interneurons.

Comprehensive profiling of anaesthetised brain dynamics across phylogeny

This study profiles neural dynamics across species during anaesthesia, finding conserved dynamical changes and linking them to molecular mechanisms.

Age-associated changes to neuronal dynamics involve a disruption of excitatory/inhibitory balance in C. elegans

This study identifies age-related disruptions in excitatory/inhibitory balance in C. elegans neurons, showing that inhibitory signaling loss and calcium channel mutations contribute to functional decline.