Science AdvancesSystems BiologyPeer-reviewed journal article
Self-assembly based post-translational protein oscillators
Ofer KimchiiD, Carl P. GoodrichiD, Alexis CourbetiD, Agnese I. CuratoloiD, Nicholas B. WoodalliD, David A. BakeriD, Michael P. BrenneriD
Abstract
Recent advances in synthetic post-translational protein circuits are significantly impacting the landscape of biomimicry engineering. However, designing sustained dynamic phenomena in these circuits remains an outstanding challenge. Inspired by the KaiABC system regulating the circadian clock in cyanobacteria, we develop two experimentally realizable post-translational oscillators. The oscillators rely on a small number of components interacting only through reversible binding and phosphorylation/dephosphorylation reactions.
- Citations
- 12
- FWCI
- 0.24
- Field percentile
- 47th percentile
Reproducibility ledger
Nobody has reported trying to reproduce this paper yet. Did you replicate an experiment or run the code? Your report saves the next lab a week.
Sign in to file a reproducibility report.
Related papers
- Simple post-translational circadian clock models from selective sequestration
Mark O. Byrne·bioRxiv·Feb 21, 2020
- Elucidation of Master Allostery Essential for Circadian Clock Oscillation in Cyanobacteria
Y. Furuike, A. Mukaiyama, … S. Akiyama·bioRxiv·Aug 30, 2021
- Intracellularly Coupled Oscillators for Synthetic Biology
Gábor Holló, Jung Hun Park, … Yolanda Schaerli·Nature CommunicationsPeer-reviewed·Dec 21, 2025
- Reconstitution of an intact clock that generates circadian DNA binding in vitro
A. G. Chavan, D. C. Ernst, … A. LiWang·bioRxiv·Jun 18, 2020
- Mechanism of autonomous synchronization of the circadian KaiABC rhythm
M. Sasai·bioRxiv·Nov 24, 2020
- Kinetic hierarchy of Kai protein complex formation governs the cyanobacterial circadian oscillator
Ken Morishima, Yasuhiro Yunoki, … Masaaki Sugiyama·bioRxiv·Mar 7, 2026