Ofer Kimchi

Intersegmental transfers drive target search in an RNA-targeting CRISPR system

This study shows that Cas13 uses intersegmental transfers to efficiently search for RNA targets, differing from DNA-binding proteins.

Genome-wide mapping of mesoscale neuronal RNA organization and condensation

The paper introduces RNA-SPRITE to map RNA-RNA spatial proximity genome-wide, revealing conserved mRNA organization and colocalization driven by shared motifs and functional relationships.

Bacterial defense and phage counter-defense lead to coexistence in a modeled ecosystem

The paper develops a mathematical model to study bacterial-phage coexistence, showing stable coexistence arises from evolutionary dynamics of defense and counter-defense systems.

RNA structure modulates Cas13 activity and enables mismatch detection

This study investigates how RNA structure affects Cas13 activity, revealing two mechanisms by which secondary structure modulates Cas13 and improving RNA detection through strand displacement.

Self-assembly based post-translational protein oscillators

This paper designs two post-translational protein oscillators inspired by the KaiABC system, using reversible binding and phosphorylation/dephosphorylation reactions.

Sequence analysis of SARS-CoV-2 genome reveals features important for vaccine design

The paper analyzes SARS-CoV-2 genomic features to identify targets for vaccine development through codon pair deoptimization.