Author

M. Sasai

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 6 Microbiology· 3 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 8 Organism:human· 5 Approach:experimental assay· 4 Research Focus:chromatin & epigenetic regulation· 3 Research Focus:drug response / drug discovery· 3 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:structural biology· 2

Frequent Co-Authors

M. Yamamoto· 4 shared A. A. Sherif· 2 shared D. M. Standley· 2 shared N. Sakai· 2 shared R. Nitta· 2 shared A. Harada· 1 shared A. Pradipta· 1 shared B. Bhattacharyya· 1 shared

Activity by Year

2018-2024 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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4 shared papersMicrobiology

M. Yamamoto

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Author profile →

11 papers

Recent·Most cited

In vivo CRISPR screens identify novel virulence genes among proteins of unassigned subcellular localization in Toxoplasma

Y. Tachibana, M. Sasai, M. Yamamoto

The paper uses in vivo CRISPR screens to identify virulence genes among Toxoplasma proteins with unassigned subcellular localizations, finding two essential genes conserved in Apicomplexa.

bioRxiv · Jan 28, 2024 · PreprintMicrobiology

Structural basis of Irgb6 inactivation by Toxoplasma gondii through the phosphorylation of switch I.

H. Okuma, Y. Saijo-Hamano, A. A. Sherif, E. Hoshizaki, N. Sakai, T. Kato, T. Imasaki, E. Nitta, M. Sasai, Y. Maniwa, H. Kosako, D. M. Standley, M. Yamamoto, R. Nitta

The paper reveals how Toxoplasma gondii inactivates Irgb6 through ROP18-mediated phosphorylation, preventing its function in host defense.

bioRxiv · Oct 31, 2022 · PreprintMicrobiology

Role of the reaction-structure coupling in temperature compensation of the KaiABC circadian rhythm

M. Sasai

The paper models how reaction-structure coupling in KaiC affects temperature compensation in the KaiABC circadian clock, showing reduced coupling increases oscillation period and amplitude.

bioRxiv · Oct 11, 2021Biophysics

Structural basis of membrane recognition of Toxoplasma gondii vacuole by Irgb6

Y. S. Hamano, A. A. Sherif, A. Pradipta, M. Sasai, N. Sakai, Y. Sakihama, M. Yamamoto, D. M. Standley, R. Nitta

This study determines the crystal structures of Irgb6 in GTP-bound and nucleotide-free forms, revealing a unique PVM binding interface that explains its membrane recognition mechanism.

bioRxiv · Jul 1, 2021Microbiology

Generation of dynamic three-dimensional genome structure through phase separation of chromatin

S. Fujishiro, M. Sasai

The paper develops a polymer model of human interphase nuclei to show that chromatin phase separation driven by heterogeneous repulsion explains genome structure and dynamics.

bioRxiv · May 6, 2021 · PreprintBiophysics

Evaluation of the Efficacy and Safety of a Clinical Grade Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Patch: A Pre-Clinical Study

S. Miyagawa, T. Kawamura, E. Ito, M. Takeda, H. Iseoka, J. Yokoyama, A. Harada, N. Mochizuki-Oda, Y. Imanishi-Ochi, J. Li, M. Sasai, F. Kitaoka, M. Nomura, N. Amano, T. Takahashi, , Y. Sawa

This pre-clinical study evaluates the safety and efficacy of clinical-grade human iPSC-derived cardiomyocyte patches in treating heart failure, showing improved cardiac function and no adverse effects.

bioRxiv · Apr 7, 2021 · PreprintCell Biology

Anti-CoVid19 plasmid DNA vaccine induces a potent immune response in rodents by Pyro-drive Jet Injector intradermal inoculation

T. Nishikawa, C. Y. Chang, J. A. Tai, H. Hayashi, J. Sun, S. Torii, C. Ono, Y. Matsuura, R. Ide, J. Mineno, M. Sasai, M. Yamamoto, H. Nakagami, K. Yamashita

This study evaluates a plasmid DNA vaccine against SARS-CoV-2 using a pyro-drive jet injector, showing strong immune response and protection in rodents.

bioRxiv · Jan 13, 2021 · PreprintImmunology

Mechanism of autonomous synchronization of the circadian KaiABC rhythm

M. Sasai

This paper proposes a theoretical model explaining how KaiABC proteins synchronize their phosphorylation oscillations through KaiC hexamer stochastic transitions and KaiA sequestration.

bioRxiv · Nov 24, 2020Biophysics

Stochastic Epigenetic Dynamics of Gene Switching

B. Bhattacharyya, J. Wang, M. Sasai

This study theoretically analyzes the dynamical effects of histone modifications on gene switching using chemical reaction kinetics, revealing hysteresis and nonlinear nonequilibrium mechanisms.

bioRxiv · Mar 18, 2020Biophysics

Organization of fast and slow chromatin revealed bysingle-nucleosome dynamics

S. S. Ashwin, T. Nozaki, K. Maeshima, M. Sasai

The paper analyzes single-nucleosome dynamics in living human cells to reveal fast and slow chromatin domains, showing their dynamic organization through statistical analysis and a polymer model.

bioRxiv · Aug 16, 2019Biophysics

Single-molecular and Ensemble-level Oscillations of Cyanobacterial Circadian Clock

S. Das, T. P. Terada, M. Sasai

The paper introduces two theoretical models to explain how ATP hydrolysis drives and synchronizes oscillations in cyanobacterial circadian clocks at both single-molecule and ensemble levels.

bioRxiv · Mar 7, 2018Biophysics