DisPhaseDB, an integrative database of diseases related variations in liquid-liquid phase separation proteins

MotivationProteins involved in liquid-liquid phase separation (LLPS) and membraneless organelles (MLOs) are recognized to be decisive for many biological processes and also responsible for several diseases. The recent explosion of research in the area still lacks tools for the analysis and data integration among different repositories. Currently, there is not a comprehensive and dedicated database that collects all disease-related variations in combination with the protein location, biological role in the MLO and all the metadata available for each protein and disease. Disease related protein variants and additional features are dispersed and the user has to navigate many databases, with different focus, formats and often not user friendly. ResultsWe present DisPhaseDB, a database dedicated to disease related variants of LLPS proteins and/or are involved in MLOs. It integrates 10 databases, contains 5.741 proteins, 1.660.059 variants and 4.051 disease terms. It also offers intuitive navigation and an informative display. It constitutes a pivotal starting point for further analysis, encouraging the development of new computational tools. Availability and ImplementationThe database is freely available at http://disphasedb.leloir.org.ar. Contactjiserte@leloir.org.ar and cmb@leloir.org.ar Graphical abstract O_FIG O_LINKSMALLFIG WIDTH=200 HEIGHT=169 SRC="FIGDIR/small/479026v1_ufig1.gif" ALT="Figure 1"> View larger version (43K): org.highwire.dtl.DTLVardef@b4e706org.highwire.dtl.DTLVardef@ab75bforg.highwire.dtl.DTLVardef@bf70cborg.highwire.dtl.DTLVardef@8622e3_HPS_FORMAT_FIGEXP M_FIG C_FIG