Qian Li

Arginine methylation coordinates with phosphorylation to regulate NADP+ synthesis

This study identifies PRMT6-mediated arginine methylation of NADK that suppresses its kinase activity and NADP+ synthesis, revealing a regulatory mechanism involving coordination with Akt phosphorylation and implications for cancer progression.

SARS-CoV-2 nucleocapsid induces hyperinflammation and vascular leakage through the Toll-like receptor signaling axis in macrophages

This study shows the SARS-CoV-2 nucleocapsid protein drives hyperinflammation and vascular leakage in macrophages via Toll-like receptor signaling, contributing to severe COVID-19 complications.

A unified developmental framework of the human placenta in its uterine environment in vivo and in vitro

This study integrates single-cell data to create a unified framework of human placental development, revealing cell subtypes, vascular niches, and trophoblast dynamics across gestation.

Circulating pre-osteoclasts are primed for osteoclast fate and synovial tissue homing in psoriatic arthritis.

Endothelial PTBP1 Deletion in Transplanted Cardiac Tissue Limits Cardiac Allograft Vasculopathy

This study identifies PTBP1 as a key regulator of endothelial dysfunction in cardiac allograft vasculopathy, showing its deletion reduces fibrosis and immune activation in mouse models.

Development of a Novel Benzodiazepine to Delineate Peripheral GABA-A Signaling Mechanisms in Visceral Pain Syndromes

This study develops a novel benzodiazepine, Li633, that targets peripheral GABAA receptors to reduce visceral pain in IBS and FD models.

A model of apical-out human first trimester trophoblast organoids to study regeneration after syncytial damage

The paper develops an in vitro model of human first-trimester trophoblast organoids to study syncytiotrophoblast regeneration after damage and identifies TNFRSF12A as a potential enhancer of this process.

Microbial Tryptophan Metabolism Activates Host Lysosomal Activity to Facilitate Lipid Breakdown and Ameliorate Hepatic Steatosis

This study identifies how bacterial tryptophan metabolism activates lysosomal function to promote lipid breakdown and reduce hepatic steatosis in both C. elegans and mice.

Integrated Analysis of Single-Cell and Bulk RNA-Seq Data reveals that Ferroptosis-Related Genes Mediated the Tumor Microenvironment predicts Prognosis, and guides Drug Selection in Triple-Negative Breast Cancer

This study integrates single-cell and bulk RNA-seq data to identify ferroptosis-related genes in TNBC, developing a risk score model to predict prognosis and guide drug selection.

Prediction of liquid-liquid phase separation proteins using machine learning

The paper develops a machine learning tool, PSPredictor, to predict phase separation proteins using sequence information, achieving high accuracy and outperforming existing methods.

MicroRNAs Regulate the Wnt/Ca2+ Signaling Pathway to Promote the Secretion of Insulin in Pancreatic Nestin-Positive Progenitor Cells

The paper investigates how miRNAs regulate insulin secretion in pancreatic beta cells by controlling intracellular Ca2+ through the Wnt/Ca2+ signaling pathway.