MOVICS: an R package for multi-omics integration and visualization in cancer subtyping

Abstract

SummaryStratification of cancer patients into distinct molecular subgroups based on multi-omics data is an important issue in the context of precision medicine. Here we present MOVICS, an R package for multi-omics integration and visualization in cancer subtyping. MOVICS provides a unified interface for 10 state-of-the-art multi-omics integrative clustering algorithms, and incorporates the most commonly used downstream analyses in cancer subtyping researches, including characterization and comparison of identified subtypes from multiple perspectives, and verification of subtypes in external cohort using a model-free approach for multiclass prediction. MOVICS also creates feature rich customizable visualizations with minimal effort. Availability and implementationMOVICS package and online tutorial are freely available at https://github.com/xlucpu/MOVICS.