Effects of aging on upper body express visuomotor responses while reaching under varying postural demands

Abstract

Humans can react remarkably quickly to novel or displaced visual stimuli when time is of the essence. Such movements are thought to be initiated by a subcortical fast visuomotor network, but it is unclear how this network declines with age. Past work in the upper limb has detailed delayed reaching corrections to jumped visual stimuli in the elderly, but the underlying mechanisms contributing to these changes of the fast visuomotor network are poorly understood. Conversely, work in the lower limb has reported delayed muscle recruitment during obstacle avoidance, but such findings may be confounded by age-related challenges in postural control. The output of the fast visuomotor network can be quantified by measuring express visuomotor responses (EVRs), which are the earliest and very short-latency bursts of muscle activity that follow visual target presentation. Here, we compare the prevalence, latency, and magnitude of EVRs in elderly (58-80 years old) and younger (18-25 years old) participants performing visually-guided reaches. We also investigated the impact of postural stability by having participants reach either while seated on a stable chair, or on a wobble stool. Both the elderly and younger cohorts expressed EVRs, but EVRs in the elderly were comparatively less frequent, and had longer latencies and smaller magnitude. Postural instability had no effects on these outcomes. Our results suggest age-related declines in the fast visuomotor network, potentially resulting from deterioration of underlying circuits and a prioritization of stability over speed. This study serves as an important standard for future research investigating clinical populations. HighlightsO_LIDo aging and postural stability affect express visuomotor responses (EVRs)? C_LIO_LIEVRs were recorded from the pectoralis muscle during rapid goal-directed reaches C_LIO_LIEVRs were smaller and delayed, and movement was slower, in elderly participants C_LIO_LIAge-related differences were independent of our postural stability manipulation C_LIO_LIOur results suggest age-related declines of the fast visuomotor network C_LI