Brian D. Corneil

Subcortical control of reaching in humans

This study investigates subcortical control of reaching in humans using a visuomotor task, finding coordinated muscle responses that suggest subcortical systems can compute musculoskeletal dynamics for reaching.

Lower-limb express visuomotor responses are spared in Parkinson's Disease during step initiation from a stable position

This study examines express visuomotor responses (EVRs) in Parkinson's Disease patients and healthy controls during step initiation, finding EVRs are preserved in low postural demand but absent in high demand, with disease severity affecting EVR magnitude.

Continuous theta-burst stimulation of the prefrontal cortex in the macaque monkey: no behavioral evidence for within-target inhibition or neural evidence for cross-hemisphere disinhibition

This study tests assumptions about cTBS effects on neural inhibition and disinhibition in macaques, finding no behavioral or neural evidence supporting these hypotheses.

Effects of aging on upper body express visuomotor responses while reaching under varying postural demands

This study examines how aging and postural stability affect express visuomotor responses (EVRs) during reaching tasks, finding that elderly participants show smaller, delayed EVRs and slower movements, independent of postural demands.

Cortical dynamics underlying initiation of rapid steps with contrasting postural demands

The paper examines cortical dynamics during rapid stepping movements under different postural demands, finding greater cortical involvement in high-demand steps.

Focal control of non-invasive deep brain stimulation using multipolar temporal interference

This paper introduces multipolar temporal interference (mTI), a method that improves focal control of non-invasive deep brain stimulation in animals.

Are online corrections to visual targets really a distinct class of movement?

The paper investigates whether online corrections to visual targets are a distinct movement class by analyzing muscle recruitment, force, and kinematics in a target-jumping task.

Parkinson's Disease affects the contextual control, but not the expression, of a rapid visuomotor response that initiates visually-guided reaching: Evidence for multiple, interacting motor pathways and implications for motor symptoms in Parkinson's Disease

This study shows that Parkinson's disease preserves the speed and strength of a reflexive visuomotor response but impairs its contextual modulation, suggesting distinct motor pathways are affected.

Rapid integration of face detection and task set in visually guided reaching

The paper investigates how face detection influences rapid motor responses during visual tasks, finding that EVRs are modulated by task instructions and face salience.

Startling acoustic stimuli hasten reflexive choice reaching tasks by strengthening, but not changing the timing of, express visuomotor responses

This paper investigates how startling acoustic stimuli shorten reaction times in reflexive reaching tasks by enhancing express visuomotor responses without altering their timing.

Evidence for an Intricate Relationship Between Express Visuomotor Responses, Postural Control and Rapid Step Initiation in the Lower Limbs

This study investigates how express visuomotor responses (EVRs) in lower limbs interact with postural control during stepping, finding that EVRs are suppressed under high postural demands.

Done in 65 ms: Express visuomotor responses in upper limb muscles in Rhesus Macaques

This study shows that Rhesus Macaques exhibit express visuomotor responses in upper limb muscles with latencies of ~65 ms, similar to humans but faster, suggesting shared but distinct visuomotor transformation mechanisms.

Single-trial dynamics of competing reach plans in the human motor periphery

The paper analyzes single-trial muscle activity during a reach task to show how competing motor plans influence movement, revealing an initial averaged command that transitions to a resolved single command.

A complex reach direction rule that delays reaction time causes alternating excitation and inhibition in express muscle responses and corticospinal excitability

This study investigates neural control signals during reaching by isolating express and voluntary responses, revealing alternating excitation and inhibition in muscle activity and corticospinal excitability.

A subcortical origin for rapid, target-oriented corticospinal excitability modulation during visually guided reaching

The paper investigates the origin of rapid corticospinal excitability changes during visually guided reaching and finds subcortical, not cortical, modulation of motor evoked potentials.

Express visuomotor responses reflect knowledge of both target location and conscious intent during reaches of different amplitudes

Cue-driven motor planning facilitates express visuomotor responses in human arm muscles

The paper shows that symbolic cues modulate express visuomotor responses in human arm muscles, suggesting motor plan-level modulation rather than early visuospatial processing.

Express Arm Responses Appear Bilaterally on Upper-limb Muscles in An Arm Choice Reaching Task

The paper shows express arm responses occur bilaterally in upper-limb muscles during reaching tasks, supporting the involvement of the reticulo-spinal tract.

Trial-by-trial modulation of express visuomotor responses induced by symbolic or barely detectable cues

The paper investigates how symbolic and barely detectable cues modulate express visuomotor responses, showing both top-down and bottom-up influences on a subcortical network.

High contrast, moving targets in an emerging target paradigm promote fast visuomotor responses during visually guided reaching

The paper investigates how visual features like high contrast and fast movement influence rapid visuomotor responses during reaching, showing that these features elicit strong muscle responses and faster reaction times.

The influence of temporal predictability on express visuomotor responses

This study investigates how temporal predictability affects express visuomotor responses, finding that predictable target timing enhances the frequency and strength of stimulus-locked responses.

Frontal eye field inactivation alters the readout of superior colliculus activity for saccade generation in a task-dependent manner

This study investigates how FEF inactivation affects iSC activity during saccade generation across different tasks, finding task-dependent reductions in spike counts.

An emerging target paradigm evokes fast visuomotor responses on human upper limb muscles

This paper introduces a new behavioral paradigm that consistently evokes robust fast visuomotor responses in human upper limb muscles during visually guided reaches.

Impairment but not abolishment of express saccades after unilateral- or bilateral cryogenic FEF inactivation

The paper investigates the role of the frontal eye fields (FEF) in express saccades by inactivating FEF in monkeys, finding that FEF facilitates but does not critically enable express saccades.

Stimulus-Locked Responses on Human Upper Limb Muscles and Corrective Reaches are Preferentially Evoked by Low Spatial Frequencies

The paper investigates how visual stimuli with different spatial frequencies affect rapid visuomotor responses, finding that low spatial frequencies evoke the fastest and most prevalent responses.

A rapid visuomotor response on the human upper limb is selectively influenced by implicit, but not explicit, motor learning

This study shows that implicit motor learning, but not explicit strategies, influences the earliest neuromuscular activity during a rapid visuomotor response.

Frontal eye field inactivation reduces saccade preparation in the superior colliculus, but does not alter how preparatory activity relates to saccade latency

This study investigates the role of the frontal eye fields (FEF) in saccade preparation by inactivating FEF in rhesus monkeys and analyzing its effect on superior colliculus (SC) preparatory activity and saccadic reaction times (SRTs).

Done in 100 ms: Path-dependent visuomotor transformation in the human upper limb

The paper shows that task complexity affects the magnitude, not latency, of a circuit transforming visual input into motor actions, with a fixed 100 ms latency.

Frontal Eye Field inactivation diminishes Superior Colliculus activity, but delayed saccadic accumulation governs reaction time increases

The paper investigates how FEF inactivation affects iSC activity and saccadic reaction time, finding that delayed accumulation onset, not reduced accumulation rate or threshold, best explains increased SRT.