bioRxivBioinformaticsPreprint
Time-dependent synergy for multi-agent anticancer therapy
Abstract
A synergy between two therapeutic agents occurs when the effect of using both is greater than the sum of the effects of using each of them separately. There are several methods of detecting synergies in the literature, but they do not take into account the relationship between the times in which the factors act. In the article, we propose and justify the use of second-order sensitivity analysis as a potential tool for the detection and visualization of this type of synergy. We test and illustrate the proposed approach using four exemplary models of combined radio-chemotherapy of cancer.
- Citations
- 0
Reproducibility ledger
Nobody has reported trying to reproduce this paper yet. Did you replicate an experiment or run the code? Your report saves the next lab a week.
Sign in to file a reproducibility report.
Related papers
- The role of synergy and antagonism in designing multidrug adaptive chemotherapy schedules
- SynergyFinder Plus: Toward Better Interpretation and Annotation of Drug Combination Screening Datasets
Shuyu Zheng, Wenyu Wang, … Jing Ping Tang·Genomics Proteomics & BioinformaticsPeer-reviewed·Jan 24, 2022
- Optimal Therapy Scheduling Based on a Pair of Collaterally Sensitive Drugs
N. Yoon, R. Vander Velde, … J. Scott·bioRxiv·Feb 20, 2018
- Drug combination sensitivity scoring facilitates the discovery of synergistic and efficacious drug combinations in cancer
A. Malyutina, M. M. Majumder, … J. Tang·bioRxiv·Jan 4, 2019
- Methods for High-Throughput Drug Combination Screening and Synergy Scoring
Liye He, Evgeny Kulesskiy, … Jing Tang·bioRxiv·May 5, 2016
- Ultrasensitive response explains the benefit of combination chemotherapy despite drug antagonism
S. C. Patterson, A. E. Pomeroy, A. C. Palmer·bioRxiv·Feb 27, 2023