Neurology GeneticsGeneticsPeer-reviewed journal article
Atrial Fibrillation Genetic Risk Differentiates Cardioembolic Stroke from other Stroke Subtypes
Sara L. PulitiD, Lu-Chen C WengiD, Patrick F. McArdleiD, Ludovic TrinquartiD, Seung Hoan ChoiiD, Braxton D. MitchelliD, Jonathan M. RosandiD, Paul I. W. de BakkeriD, Emelia J. BenjaminiD, Patrick T. EllinoriD, Steven J. KittneriD, Steven A. LubitziD, Christopher D. AndersoniD, Ingrid E. Christophersen, Michiel RienstraiD, Carolina RoselliiD, Xiaoyan YiniD, Bastiaan Geelhoed, John BarnardiD, Honghuang LiniD, Dan E. ArkingiD, Albert V. SmithiD, Christine M. AlbertiD, Mark D. ChaffiniD, Nathan R. TuckeriD, , Eric BoerwinkleiD
Abstract
ObjectiveWe sought to assess whether genetic risk factors for atrial fibrillation can explain cardioembolic stroke risk.\n\nMethodsWe evaluated genetic correlations between a prior genetic study of AF and AF in the presence of cardioembolic stroke using genome-wide genotypes from the Stroke Genetics Network (N = 3,190 AF cases, 3,000 cardioembolic stroke cases, and 28,026 referents). We tested whether a previously-validated AF polygenic risk score (PRS) associated with cardioembolic and other stroke subtypes after accounting for AF clinical risk factors.\n\nResultsWe observed strong correlation between previously reported genetic risk for AF, AF in the presence of stroke, and cardioembolic stroke (Pearsons r=0.77 and 0.76, respectively, across SNPs with p 0.1).\n\nConclusionsGenetic risk for AF is associated with cardioembolic stroke, independent of clinical risk factors. Studies are warranted to determine whether AF genetic risk can serve as a biomarker for strokes caused by AF.
- organism: human
- assay: GWAS summary statistics
- research focus: GWAS / association mapping
- approach: statistical model
- Citations
- 51
- FWCI
- 4.15
- Field percentile
- top 5%
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