Sean Harrison

Mendelian randomization revealing the protective effect of sodium-glucose cotransporter 2 inhibition on prostate cancer with verified evidence from electronic healthcare and biological data

This paper uses Mendelian randomization and electronic health records to show SGLT2 inhibitors reduce prostate cancer risk, with additional evidence from differential expression analysis.

Educational attainment as a modifier of the effect of polygenic scores for cardiovascular risk factors: cross-sectional and prospective analysis of UK Biobank

This study examines how educational attainment modifies polygenic scores for cardiovascular risk factors using UK Biobank data, finding mixed effects across traits.

Within-family studies for Mendelian randomization: avoiding dynastic, assortative mating, and population stratification biases

This paper introduces within-family Mendelian randomization methods to reduce biases from family structure and shows they yield different results compared to population-based analyses.

An atlas of polygenic risk score associations to highlight putative causal relationships across the human phenome

This study creates a polygenic risk score atlas linking genetic liability to 551 traits, revealing causal relationships like schizophrenia's inverse link to cognitive function.