Steven J. Kittner

Genetic association analysis of age of ischemic stroke onset: a caveat

The paper performs a GWAS in a case-only design to identify genetic loci influencing age at onset of ischemic stroke and finds a robust association with the APOE locus, suggesting potential survival bias rather than direct causation.

Deep resequencing of the 1q22 locus in non-lobar intracerebral hemorrhage

The paper performs deep resequencing of the 1q22 locus in non-lobar ICH cases and controls to identify causal variants and mechanisms.

Exome Array Analysis of 9,721 ischemic stroke cases from the SiGN Consortium

The paper analyzes exome array data from 9,721 ischemic stroke cases to identify coding variants associated with stroke, finding 15 significant variants, including 13 novel associations.

Genomic Risk Scores and Oral Contraceptive-Associated Ischemic Stroke Risk

The paper evaluates whether a genomic risk score modifies the risk of ischemic stroke associated with oral contraceptive use in premenopausal women.

MRI Radiomic Signature of White Matter Hyperintensities Is Associated with Clinical Phenotypes

This paper develops a radiomic signature from T2-FLAIR MRI images to predict white matter hyperintensities burden and links it to clinical phenotypes.

Sex-specific lesion topographies explain outcomesafter acute ischemic stroke

This study identifies sex-specific lesion patterns in acute ischemic stroke that correlate with stroke severity, highlighting differences in lesion distribution between men and women.

Alternate approach to stroke phenotyping identifies a genetic risk locus for small vessel stroke

The paper compares two phenotyping approaches for ischemic stroke subtypes and identifies a genetic risk locus for small vessel stroke using the intersect phenotype.

The Subtype Specificity of Genetic Loci Associated with Stroke in 16,664 cases and 32,792 controls

The paper identifies subtype-specific genetic loci associated with stroke subtypes and finds heterogeneity in their effects across different stroke types.

White Matter Hyperintensity Quantification in Large-Scale Clinical Acute Ischemic Stroke Cohorts - The MRI-GENIE Study

The paper presents an automated pipeline for quantifying white matter hyperintensity in acute ischemic stroke cohorts, showing improved accuracy and enabling large-scale analysis.

Atrial Fibrillation Genetic Risk Differentiates Cardioembolic Stroke from other Stroke Subtypes

The paper assesses if genetic risk for atrial fibrillation explains cardioembolic stroke risk using genome-wide data from the Stroke Genetics Network.