The paper compares epigenetic age acceleration between men and women with spontaneous intracerebral hemorrhage, finding men show greater acceleration than women.

bioRxiv · Oct 1, 2025 · PreprintNeuroscience

The Ethnic/Racial Variations of Intracerebral Hemorrhage Genetics (ERICH-GENE) Study Protocol

Guido J. Falcone, Stacey Q Wolfe, Marialuisa Zedde, Rosario Pascarella, Jordi Jiménez-Conde, Marta Vallverdú-Prats, Joan Jiménez-Baladó, Alessandro Pezzini, Sandra Rossi, Rustam Al‐Shahi Salman, Neshika Samarasekera, Ramin Zand, Jiaying Li, Christina Jern, Daniel Strbian, , the ERICH-Gene Investigators

ERICH-GENE collects and analyzes genomic and neuroimaging data from over 10,000 multi-ethnic ICH cases to identify genetic risk factors and trans-ethnic variation in ICH.

medRxiv · Jun 11, 2025 · PreprintGenetic & Genomic Medicine

MULTITRAIT ANALYSIS EXPANDS GENETIC RISK FACTORS IN CARDIOEMBOLIC STROKE

Jara Cárcel‐Márquez, Elena Muiño, Cristina Gallego-Fábrega, Natàlia Cullell, Miquel Lledós, Laia Llucià‐Carol, Tomás Sobrino, Francisco Campos, José Castillo, María del Mar Freijo, Juan Francisco Arenillas, Vı́ctor Obach, José Álvarez‐Sabín, Carlos Alberto Molina, Marc Ribó, , Israel Fernández‐Cadenas

This study identifies eight new genetic loci associated with cardioembolic stroke using multitrait analysis of GWAS data, revealing distinct genetic pathways from atrial fibrillation.

Frontiers in Cardiovascular Medicine · Jul 8, 2022Peer-reviewedGenetic & Genomic Medicine

MULTI-ANCESTRY GENETIC STUDY IN 5,876 PATIENTS IDENTIFIES AN ASSOCIATION BETWEEN EXCITOTOXIC GENES AND EARLY OUTCOMES AFTER ACUTE ISCHEMIC STROKE

Laura Ibáñez, Laura Heitsch, Caty Carrera, Fabiana H G Farias, Jorge L. Del‐Aguila, Rajat Dhar, John Budde, Kristy Bergmann, Joseph L. Bradley, Oscar Harari, Chia‐Ling Phuah, Robin Lemmens, Alessandro A. Viana Oliveira Souza, Francisco Moniche, Antonio Cabezas-Juan, , Carlos Cruchaga

This paper identifies seven genome-wide significant loci associated with early neurological instability after acute ischemic stroke, linking excitotoxic genes to poor outcomes.

Brain · Feb 24, 2022Peer-reviewedGenetic & Genomic Medicine