Feline leukaemia virus subgrouping using the viral interference assay

Dimas Arya Abdillah; Takahiro Hiratsuka; Fumiko Matsuyama; Yuki Hattori; Takehisa SOMA; Tetsuya SHIMODA; Takashi Kato; Hideo Sakai; Masaharu Hisasue; Ariko Miyake; Kazuo Nishigaki

doi:10.1101/2025.07.21.665799

MicrobiologybioRxivJul 21, 2025

Preprint

Feline leukaemia virus subgrouping using the viral interference assay

Dimas Arya Abdillah, Takahiro Hiratsuka, Fumiko Matsuyama, Yuki Hattori iD, Takehisa SOMA iD, Tetsuya SHIMODA, Takashi Kato iD, Hideo Sakai, Masaharu Hisasue iD, Ariko Miyake iD, Kazuo Nishigaki iD

Abstract

Feline leukaemia virus subgroup A (FeLV-A) is transmitted among cats, and FeLV subgroups are frequently generated de novo. We investigated the frequency of detection of subgroups using interference assays in 50 cases. FeLV-A infection alone was detected in 38% of cases, whereas co-infection with both FeLV-A and FeLV-B was observed in 62% of cases. No cases of FeLV-B infection alone were observed. Cases of co-infection with FeLV-A and FeLV-B showed a higher prevalence than cases of FeLV-A infection alone. The X region containing FeLV was discovered in two new cases. This study may elucidate the mechanism underlying FeLV-B-induced diseases.

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