Neural correlates of memory in a naturalistic spatiotemporal context

We investigated memory encoding and retrieval during a quasi-naturalistic spatial-episodic memory task in which subjects delivered items to landmarks in a desktop virtual environment and later recalled the delivered items. Transition probabilities and latencies revealed the spatial and temporal organization of memory. As subjects gained experience with the town, their improved spatial knowledge led to more efficient navigation and increased spatial organization during recall. Subjects who exhibited stronger spatial organization exhibited weaker temporal organization. Scalp-recorded electroencephalographic (EEG) signals revealed spectral correlates of successful encoding and retrieval. Increased theta power (T +) and decreased alpha/beta power (A-) accompanied successful encoding, with the addition of increased gamma (G+) accompanying successful retrieval. Logistic-regression classifiers trained on spectral features reliably predicted mnemonic success in held-out sessions. Univariate and multivariate EEG analyses revealed a similar spectral T +A-G+ of successful memory. These findings extend behavioral and neural signatures of successful encoding and retrieval to a naturalistic task in which learning occurs within a spatiotemporal context.