Intermittent Cranial Accelerometric Pulses - a Potential Marker of Neurodegenerative Disease

Abstract

We identified Intermittent Cranial Accelerometric Pulses (ICAPs) also known as Sleep Bursts (SBs), as a novel phenomenon of brief (1-2 sec), often periodic bursts in cranial forces occurring during human sleep. Our goal was to characterize SBs in normal subjects, then compare SB in a cohort of subjects with neurodegenerative disease (NDD). We recorded 32 cognitively healthy subjects (23 -87 years) and 13 subjects with NDD (51 - 84 years). SBs occurred in all 45 subjects. SBs occurred at 0.57 SB/min (once per 105 seconds) in controls and 0.40 SB/min (once per 150 seconds) in NDD (p = 0.0043). SB occurred with equal rates across all sleep stages in both groups. When occurring periodically, SBs had modal intervals (3.75 bursts/min (0.0625 Hz) - 2.67 bursts/min (0.044 Hz)). EEG power increased in the delta range 1-2 seconds before and following the SB. EEG delta power during a SB was significantly lower in all NDD subjects across sleep stages compared to controls. The relatively low frequency of SB events and synchronization with EEG power has no parallel in human sleep; we hypothesize that SBs may represent a brain-generated pulsatile component of brain glymphatic drainage.