The paper shows that REM sleep duration and delta activity in Parkinson's disease patients correlate with reduced daytime basal ganglia-cortical network pathology and improved alertness.

bioRxiv · May 7, 2025 · PreprintNeuroscience

Multi-night naturalistic cortico-basal recordings reveal mechanisms of NREM slow wave suppression and spontaneous awakenings in Parkinson's disease

Md Fahim Anjum, Clay N Smyth, José Rafael P. Zuzuárregui, Derk‐Jan Dijk, Philip A. Starr, Timothy Denison, Simon J Little

This study uses multi-night recordings to show that Parkinson's disease affects NREM sleep by altering cortico-basal slow wave activity and subcortical beta power, with DBS enhancing these changes and predicting spontaneous awakenings.

Nature Communications · Feb 27, 2024Peer-reviewedNeuroscience

Scalable method for micro-CT analysis enables large scale quantitative characterization of brain lesions and implants

David B. Kastner, Viktor Kharazia, Rhino Nevers, Clay N Smyth, Daniela Astudillo Maya, Greer M. Williams, Zhounan Yang, Cristofer Holobetz, Luca Della Santina, Dilworth Y. Parkinson, Loren M. Frank

This paper introduces a scalable method for micro-CT analysis to quantitatively characterize brain lesions and implants while preserving the skull.

Scientific Reports · Nov 30, 2020Peer-reviewedNeuroscience

Knock-in rats expressing Cre and Flp recombinases at the Parvalbumin locus.

Jai Y. Yu, Jeffrey R. Pettibone, Caiying Guo, Shuqin Zhang, Thomas L. Saunders, Elizabeth D. Hughes, Wanda E. Filipiak, Michael G. Zeidler, Kevin J. Bender, Frederic Woodward Hopf, Clay N Smyth, Viktor Kharazia, Anna Kiseleva, Thomas J. Davidson, Loren M. Frank, Joshua D. Berke

The paper generates and validates two knock-in rat strains expressing Cre or Flp recombinase under the Parvalbumin promoter for studying inhibitory interneurons.

bioRxiv · Aug 7, 2018 · PreprintNeuroscience