Cerebrospinal fluid and hydrocephalus

Physiological Oscillations of Lateral Ventricular Volume Revealed by Fast fMRI: Effects of Aging and Vigilance

This study uses fast fMRI to analyze physiological oscillations of lateral ventricular volume in adults, finding age-related ventricular enlargement and increased fluctuation magnitude during drowsiness.

Glymphatic System Is Enhanced in Anti-NMDAR Encephalitis and Facilitates Antibody Influx and Clearance in the Brain

This study shows that the glymphatic system is enhanced in anti-NMDAR encephalitis, facilitating antibody influx and clearance, with AQP4 polarization playing a key role.

Human Choroid Plexus Organoids Progress to Postnatal-like Maturation and Reveal a Closing Window of Developmental Plasticity

This study uses single-cell RNA sequencing to track the maturation of human choroid plexus organoids and identifies a stage-dependent window of developmental plasticity.

Spontaneous Hemodynamic Oscillations during Sleep Coordinate Directional CSF Flow in the Subarachnoid Space and Ventricles

This study shows that hemodynamic oscillations during sleep coordinate directional CSF flow in the subarachnoid space and ventricles, enhancing fluid transport.

An integrated multi-omic atlas of the choroid plexus highlights conserved molecular programs of epithelial function

This study integrates multi-omic data from mouse and human choroid plexus to identify conserved molecular programs of epithelial function across species.

Multimodal Glymphatic Imaging in Multiple Sclerosis: Associations with Sleep and Disability

This study investigates glymphatic function in MS using MRI and finds that gBOLD-CSF coupling correlates with sleep, disability, and structural changes, while DTI-ALPS shows limited utility due to microstructural confounding.

Connections across regional glymphatic clearance, neural activity and amyloid-β deposition in cortex

This study links glymphatic clearance, neural activity, and amyloid-β deposition in the cortex using MRI and transcriptomic data, showing spatial associations and potential vulnerability to neurodegeneration.

Brain-wide Cerebrospinal Fluid Recirculation Collapse in Alzheimers Disease

This paper investigates CSF flow failure in Alzheimer's disease by showing structural collapse in perivascular spaces and impaired cholesterol clearance leading to fluid stagnation.

How brain pulsations drive solute transport in thecranial subarachnoid space: insights from a toymodel

This study develops a toy model to investigate how brain pulsations drive solute transport in the cranial subarachnoid space, showing that steady flows significantly affect concentration profiles and clearance efficiency.

Probing the Glymphatic System Using Optical Imaging and Mathematical Modeling

This study uses optical imaging and mathematical modeling to analyze tracer diffusion and transport in the glymphatic system of rats under different anesthesia levels and tracer molecular weights.

Patient-informed biomechanical modelling reveals mechanical mechanism of brain damage in idiopathic normal pressure hydrocephalus

This paper develops a biomechanical model of the brain to show that ventricular enlargement in iNPH causes mechanical strain in white matter, contributing to brain damage.

Multimodal evidence for impaired glymphatic brain clearance as a mediator of "inflammaging" in schizophrenia - integrating insights from in vivo neuroimaging, omics, and post-mortem single nucleus-RNA-Seq data

The paper integrates neuroimaging, omics, and single nucleus-RNA-Seq data to show glymphatic dysfunction in schizophrenia is linked to inflammation, aging, and cognitive decline.

Intermittent Cranial Accelerometric Pulses - a Potential Marker of Neurodegenerative Disease

The paper identifies Intermittent Cranial Accelerometric Pulses (SBs) as a novel phenomenon during sleep, showing reduced frequency in neurodegenerative disease patients compared to controls.

Neurodegeneration-inducing macromolecules exit the brain via nanovascular conduits formed by reticular fibroblasts

The paper identifies nanovascular conduits formed by reticular fibroblasts that remove toxic proteins like tau and Abeta from the brain in mice and humans.

Oscillatory flow and steady streaming of cerebrospinal fluid in cranial subarachnoid space

This study models oscillatory and steady streaming flow of cerebrospinal fluid in the cranial subarachnoid space using a lubrication-based framework, showing that oscillatory forcing enhances solute transport.

Multimodal imaging maps spinal glymphatic transport in health and its disruption after injury

This study maps glymphatic transport in the spinal cord using imaging and shows that it is disrupted after injury, with impaired clearance and worsened outcomes in AQP4-knockout mice.

Low-rank tensor decompositions reveal coupled spatiotemporal patterns of CSF tracer transport in the human brain

The paper uses low-rank tensor decompositions to analyze glymphatic MRI data and identifies spatiotemporal patterns of CSF tracer transport in the human brain, revealing differences between iNPH and reference cohorts.

Effects of different slow paced breathing regimes on cerebrospinal fluid (CSF) oscillations

This study examines how different slow breathing regimes affect cerebrospinal fluid oscillations during wakefulness, finding that infraslow sighing enhances CSF-BOLD coupling.

Regional choroid plexus calcifications and their associations with aging, brain structure, and disease

This study uses quantitative susceptibility mapping to analyze choroid plexus calcifications in UK Biobank participants, finding age-related increases and associations with various health conditions.

High frame rate in vivo two-photon microscopy to quantify murine cerebrospinal fluid flow heterogeneity

This study uses high frame rate two-photon microscopy to quantify spatial heterogeneity and pulsatility of CSF flow in mice, showing it is an emergent property of the hydraulic network.

The ultrastructure of subarachnoid trabeculae in non-human primates varies by tissue region within the central nervous system

This study examines ultrastructural variations in subarachnoid trabeculae across different CNS regions in non-human primates using SEM and fixation techniques.

Kinetic analysis of CSF to brain tracer exchange in the pig brain under different anesthetic regimes

This study compares CSF-to-brain tracer exchange in pigs under two anesthetic regimens, finding higher tracer accumulation with ketamine/dexmedetomidine compared to propofol.

Ncbe is the main basolateral Na+ loading mechanism of the choroid plexus epithelium

This study identifies Ncbe as the primary Na+ loading mechanism at the basolateral membrane of choroid plexus epithelial cells, supporting its role in CSF secretion.

Scaling of anesthesia-dependent cerebrospinal fluid dynamics across rat and pig brains

This study uses SPECT/CT to compare CSF dynamics in pigs and rats under different anesthetics, finding species- and anesthesia-specific differences in tracer distribution and clearance.

Ablation of the choroid plexus attenuates hydrocephalus induced parenchymal edema but moderately reduces postnatal hippocampal neurogenesis

This study investigates the effects of choroid plexus ablation on hydrocephalus and neurogenesis, finding that it reduces parenchymal edema but only moderately affects hippocampal neurogenesis.

SPAK as a candidate mediator of TRPV4-induced NKCC1 activation and a possible pharmacological entry point in posthemorrhagic hydrocephalus

This study identifies SPAK as a key regulator of CSF secretion via TRPV4 activation and NKCC1, suggesting it as a pharmacological target for hydrocephalus.

Phosphoproteomic Insights into TRPV4 - AMPK Signaling Axis in the Choroid Plexus Epithelium: Implications for Therapeutic Targeting in Hydrocephalus

The paper investigates the TRPV4-AMPK signaling axis in choroid plexus epithelial cells using phosphoproteomics, showing that AMPK inhibition enhances barrier tightness and suggests metformin as a potential therapeutic agent for hydrocephalus.

Enhanced glymphatic CSF tracer influx during α2-adrenergic agonist anesthesia is independent of tracer injection duration

This study shows that α2-adrenergic agonist anesthesia increases glymphatic CSF influx, independent of tracer injection duration, compared to isoflurane.

Neuronal Activity-Dependent Electroosmosis and Its Potential Role in Interstitial Fluid Flow in the Glymphatic System

This paper proposes electroosmosis as a mechanism for interstitial fluid flow in the brain, showing it generates realistic velocities and explains glymphatic transport differences between sleep and wakefulness.

Aging macaques bridge the translational gap in perivascular space biology

This study shows that aging rhesus macaques exhibit age-dependent perivascular space burden, mirroring human patterns, and validates MRI-detected structures as perivascular spaces.