Cinnamon hydro alcoholic extract increased expression level of UCP3 gene in skeletal muscle of obese male Wistar Rats

UCPs are the mitochondrial inner membrane proteins regulating basal metabolism. Ucp3 in muscle and adipose tissue helping metabolism and fat oxidation affecting thermogenesis, involve in fatty acid metabolism and energy homeostasis.\n\n42 adult rats divided into 6 groups including control group, the high-fat diet Obese group, experimental groups that in addition to the high-fat diet received 50,100,200 mgKg-1 doses of cinnamon extract and the sham group with 200 mgKg-1 extract treatment. RNA extracted from muscles, cDNA synthesized and Ucp3 gene expression level was examined by real-time PCR.\n\nIn Obese rats muscle, significant decrease in UCP3 gene expression was observed but in exprimental groups there was significant increased level of UCP3 gene expression in 100, 50 mgKg-1 dose of treatment.\n\nUCP3 might be a target for pharmacological up regulation in treatment of obesity. Cinnamon might influence UCP3 expression, in a dose dependent manner and low dose was more effective.