Leah C. Solberg Woods

This paper expands the RatGTEx resource with transcriptome-wide associations across 3,160 RNA-seq samples, identifying 7,473 gene-trait links and 144,876 QTLs for 22,599 genes.

This study performs a GWAS on cocaine self-administration in rats, identifying six genome-wide significant loci, including one linked to carboxylesterase genes involved in cocaine metabolism.

The paper identifies host genetic effects on microbiome composition in rats and finds evidence of indirect genetic effects contributing to missing heritability.

This study shows that GRK5 inhibition reduces hepatic steatosis in mice on a high-fat diet without affecting body weight or metabolic parameters.

This study shows that a mutation in the transmembrane domain of Adcy3 in rats leads to sex-specific changes in adiposity, behavior, and cAMP production.

RatXcan extends transcriptome-wide association studies to rats, enabling cross-species integration of GWAS and gene expression data to identify shared genetic mechanisms of complex traits.

This study identifies genomic loci associated with cue-reactivity in rats, linking them to incentive salience and drug abuse-related traits.

This study identifies genetic loci associated with opioid use disorder-related behaviors in rats using a genome-wide association approach and network-based clustering.

This study uses a non-linear clustering approach in rats to identify distinct behavioral and neuronal profiles associated with heroin vulnerability and resiliency, reflecting human opioid use disorder heterogeneity.

This study shows that a protein-coding mutation in Adcy3 increases adiposity and alters emotional behaviors in rats, with sex-dependent effects on metabolism and behavior.

The paper shows that escalation of cocaine intake, progressive ratio responding, and continued use despite adverse consequences are highly correlated in rats, with sex differences in addiction-like behaviors.

The paper genotypes Y and mitochondrial chromosomes in heterogeneous stock rats and finds no significant associations with complex traits, except for gene expression on these chromosomes.

The paper presents an improved rat reference genome, mRatBN7.2, which enhances genomic, transcriptomic, and proteomics data mapping and identifies millions of genetic variations across rat strains.

This study shows that long-access heroin self-administration in rats reduces grey matter volume in specific brain regions and alters microglia morphology, suggesting a link between neuroinflammation and structural brain changes.

This study identifies genetic loci associated with delay discounting in Heterogenous Stock rats using GWAS, implicating Slc35f1 and Adgrl3 as potential genes involved in this behavior.

This study shows that young porcine plasma treatment reduces epigenetic age in multiple rat organs and improves physiological function.

This study shows that Krtcap3 knock-out rats exhibit increased adiposity and anxiety under chronic stress, with altered corticosterone responses and Nr3c1 expression.

The paper investigates the failure to replicate an adiposity phenotype linked to Krtcap3 in rats, hypothesizing that environmental stress changes during the COVID-19 pandemic may have influenced the results.

The paper simulates GWAS in rats to show that larger sample sizes lead to an exponential increase in the number of significant loci detected.

The paper identifies cis-QTLs and eQTLs in HS rats across five brain regions, finds colocalization with human GWAS results, and shows higher eQTL density compared to human data.

The paper identifies individual differences in oxycodone addiction-like behaviors in HS rats to uncover genetic factors contributing to vulnerability and resilience.

The paper identifies microbiome and metabolic vulnerabilities linked to oxycodone self-administration escalation and shows SCFAs have a causal role in addiction-like behaviors.

The paper tests individual differences in response to methadone, buprenorphine, and naltrexone in rats with opioid use disorder, finding varying efficacy based on addiction severity.

The paper identifies 554 consensus genes in outbred rats and humans associated with body weight and BMI, revealing shared genetic regulatory mechanisms relevant for obesity.

This study shows that high fat diet affects metabolic health similarly in male and female HS rats but only males show altered behavioral responses, with genetic factors influencing both outcomes.

This study confirms that Krtcap3 affects adiposity and demonstrates sex-specific effects on body weight, food intake, and insulin sensitivity in rats.

This study develops epigenetic clocks for rat and human tissues and shows that young plasma treatment reduces epigenetic age in multiple tissues and improves organ function.

This study shows that the PrL-PVT pathway modulates incentive value attribution to reward-cues in rats, with distinct effects in sign-trackers and goal-trackers.